胡瓊文   Chiung-Wen Hu  •  期刊論文  •  研究計畫  •　吳大猷紀念獎　•　十大傑出女青年 主題報導　•

A.    期刊論文

  1. Barbara B. Shih, Mark D. Farrar, Andy Vail, Donald Allan, Mu-Rong Chao, Chiung-Wen Hu, George D. D. Jones, Marcus S. Cook and Lesley E. Rhodes. Influence of skin melanisation and ultraviolet radiation on biomarkers of systemic oxidative stress. Free Radical Biology and Medicine, 2020, In press. (SCI; Impact factor = 6.170, Ranking in Biochemistry & Molecular Biology = 41/297 = 13.8%).

  2. Chiung-Wen Hu, Yuan-Jhe Chang, Marcus S. Cooke and Mu-Rong Chao*. DNA crosslinkomics: A tool for the comprehensive assessment of interstrand crosslinks using high resolution mass spectrometry. Analytical Chemistry, 2019, 91, 15193-15203. (SCI; Impact factor = 6.785, Ranking in Chemistry, analytical = 7/86 = 8.1%).

  3. Marcus S. Cooke, Chiung-Wen Hu*(Co-corresponding Author) and Mu-Rong Chao*. Editorial: Mass spectrometry for adductomic analysis. Frontiers in Chemistry, 2019, 7, 794. (SCI; Impact factor = 3.693, Ranking in Chemistry, multidisciplinary = 57/177 = 32.2%).

  4. Chiung-Wen Hu, Yuan-Jhe Chang, Cheng-Chieh Yen, Jian-Lian Chen, Rajendra Bose Muthukumaran and Mu-Rong Chao*. 15N-labelled nitrite/nitrate tracer analysis by LC-MS/MS: Urinary and fecal excretion of nitrite/nitrate following oral administration to mice. Free Radical Biology and Medicine, 2019, 143, 193-202. (SCI; Impact factor = 6.170, Ranking in Biochemistry & Molecular Biology = 41/297 = 13.8%).

  5. Ying-Ming Shih, Marcus S. Cooke, Chih-Hong Pan, Mu-Rong Chao* and Chiung-Wen Hu*(Co-corresponding Author). Clinical relevance of guanine-derived urinary biomarkers of oxidative stress, determined by LC-MS/MS. Redox Biology, 2019, 20, 556-565. (SCI; Impact factor = 7.126, Ranking in Biochemistry & Molecular Biology = 31/293 = 10.6%).

  6. Marcus S. Cooke, Chiung-Wen Hu (Co-first author), Yuan-Jhe Chang and Mu-Rong Chao*. Urinary DNA adductomics – A novel approach for exposomics. 2018, 121, 1033-1038. Environment International (SCI; Impact factor = 7.297, Ranking in Environmental Sciences = 7/241 = 2.9%).

  7. Mu-Rong Chao, Marcus S. Cooke, Chung-Yih Kuo, Chih-Hong Pan, Hung-Hsin Liu, Hao-Jan Yang, Szu-Chieh Chen, Yi-Chen Chiang and Chiung-Wen Hu*(Corresponding Author). Children are particularly vulnerable to environmental tobacco smoke exposure: Evidence from biomarkers of tobacco-specific nitrosamines, and oxidative stress. Environment International, 2018, 120, 238-245. (SCI; Impact factor = 7.297, Ranking in Environmental sciences = 7/241 = 2.9%).

  8. Chiung-Wen Hu, Marcus S. Cooke, Yuan-Jhe Chang and Mu-Rong Chao*. Direct-acting DNA ethylating agents associated with tobacco use primarily originate from the tobacco itself, not combustion. Journal of Hazardous Materials, 2018, 358, 397-404. (SCI; Impact factor = 6.434; Ranking in Environmental Sciences = 13/241 = 5.4%).

  9. Yuan-Jhe Chang, Marcus S. Cooke, Chiung-Wen Hu*(Co-corresponding Author) and Mu-Rong Chao*. Novel approach to integrated DNA adductomics for the assessment of in vitro and in vivo environmental exposures. Archives of Toxicology, 2018, 92, 2665-2680. (SCI; Impact factor = 5.728, Ranking in Toxicology = 7/94 = 7.4%).

  10. Chiung-Wen Hu, Yuan-Jhe Chang, Jian-Lian Chen, Yu-Wen Hsu and Mu-Rong Chao*. Sensitive detection of 8-nitroguanine in DNA by chemical derivatization coupled with online solid-phase extraction LC-MS/MS. Molecules, 2018, 23, 605. (SCI; Impact factor = 3.098; Ranking in Chemistry, multidisciplinary = 68/171 = 39.8%).

  11. Chung-Yih Kuo, Chia-Yu Hsieh, Chiung-Wen Hu, Szu-Chieh Chen and Hao-Jan Yang. PM10 concentration in relation to clinic visits for anxiety disorders: a population-based study of a high river-dust episode region in Taiwan.  Air Quality, Atmosphere & Health, 2018, 11, 221-227. (SCI; Impact factor = 2.662; Ranking in Environmental Sciences = 88/241 = 36.5%).

  12. Hao-Jan Yang, Szu-Chieh Chen, Chiung-Wen Hu, Yi-Chen Chiang, Ching-Tsan Tsai, Pin-Yu Lin, Dian-Jheng Lai and Chung-Yih Kuo. Estimation of students' exposure to metal concentrations from river-dust episodes during 1994-2012. Environmental Science and Pollution Research, 2017, 24, 5679-5689. (SCI; Impact factor = 2.800; Ranking in Environmental Sciences = 82/241 = 34%).

  13. Yi-Chen Chiang, Hao-Jan Yang, Szu-Chieh Chen, Chiung-Wen Hu, Ching-Tsan Tsai, Dian-Jheng Lai and Chung-Yih Kuo. Inhalation exposure of children to indoor PM10 and associated metals during river-dust episodes. Air Quality, Atmosphere & Health, 2017, 10, 381-388. (SCI; Impact factor = 2.662; Ranking in Environmental Sciences = 88/241 = 36.5%).

  14. Chiung-Wen Hu, Yuan-Jhe Chang, Yu-Wen Hsu, Jian-Lian Chen, Tsu-Shing Wang and Mu-Rong Chao. Comprehensive analysis of the formation and stability of peroxynitrite derived 8-nitroguanine by LC-MS/MS: Strategy for the quantitative analysis of cellular 8-nitroguanine. Free Radical Biology and Medicine, 2016, 101, 348-355. (SCI; Impact factor = 6.02, Ranking in Biochemistry & Molecular Biology = 39/292 = 13.4%).

  15. Chiung-Wen Hu, Ying-Ming Shih, Hung-Hsin Liu, Yi-Chen Chiang, Chih-Ming Chen and Mu-Rong Chao. Elevated urinary levels of carcinogenic N-nitrosamines in patients with urinary tract infections measured by isotope dilution online SPE LC-MS/MS. Journal of Hazardous Materials, 2016, 310, 207-216. (SCI; Impact factor = 6.434; Ranking in Environmental sciences = 13/241 = 5.4%).

  16. Mu-Rong Chao, Ying-Ming Shih, Yu-Wen Hsu, Hung-Hsin Liu, Yuan-Jhe Chang, Bo-Huei Lin and Chiung-Wen Hu*(Corresponding Author). Urinary nitrite/nitrate ratio measured by isotope-dilution LC-MS/MS as a tool to screen for urinary tract infections. Free Radical Biology and Medicine, 2016, 93, 77-83. (SCI; Impact factor = 6.02, Ranking in Biochemistry & Molecular Biology = 39/292 = 13.4%).

  17. Mu-RongChao, Chiung-WenHu and Jian-LianChen. Glass substrates crosslinked with tetracycline-imprinted polymeric silicate and CdTe quantum dots as fluorescent sensors. Analytica Chimica Acta, 2016, 925, 61-69. (SCI; Impact factor = 5.123, Ranking in Chemistry, analytical = 8/80 = 10.0%).

  18. Mu-Rong Chao, Chiung-Wen Hu and Jian-Lian Chen. Fluorometric determination of copper(II) using CdTe quantum dots coated with 1-(2-thiazolylazo)-2-naphthol and an ionic liquid. Microchim Acta, 2016, 183, 1323-1332. (SCI; Impact factor = 5.705, Ranking in Chemistry, analytical = 6/80 = 7.5%).

  19. Chiung-Wen Hu and Mu-Rong Chao. Measurement of urinary biomarkers of oxidative stress. Chung Shan Medical Journal, 2015, 26, 59-66.

  20. Mu-Rong Chao, Yu-Wen Hsu, Hung-Hsin Liu, Jia-Hong Lin and Chiung-Wen Hu*(Corresponding Author). Simultaneous detection of 3-nitrotyrosine and 3-nitro-4-hydroxyphenylacetic acid in human urine by online SPE LC-MS/MS and their association with oxidative and methylated DNA lesions. Chemical Research in Toxicology, 2015, 28, 997-1006. (SCI; Impact factor 3.432, Ranking in Toxicology = 21/94 = 22.3%).

  21. Chiung-Wen Hu, Marcus S. Cooke, Yi-Hung Tsai and Mu-Rong Chao. 8-Oxo-7,8-dihydroguanine and 8-oxo-7,8-dihydro-2­-deoxyguanosine concentrations in various human body fluids: implications for their measurement and interpretation. Archives of Toxicology, 2015, 89, 201-210. (SCI; Impact factor = 5.728, Ranking in Toxicology = 7/94 = 7.4%).

  22. Chiung-Wen Hu, Jian-Lian Chen, Yu-Wen Hsu, Cheng-Chieh Yen and Mu-Rong Chao. Trace analysis of methylated and hydroxymethylated cytosines in DNA by isotope-dilution LC-MS/MS: first evidence of DNA methylation in Caenorhabditis elegans. Biochemical Journal, 2015, 465, 39-47. (SCI; Impact factor = 3.857, Ranking in Biochemistry & Molecular Biology = 81/292 = 27.7%).

  23. Mu-Rong Chao, Chiung-Wen Hu and Jian-Lian Chen. Comparative syntheses of tetracycline-imprinted polymeric silicate and acrylate on CdTe quantum dots as fluorescent sensors. Biosensors & Bioelectronics, 2014, 61, 471-477. (SCI; Impact factor = 8.173, Ranking in Chemistry, analytical = 2/80 = 2.5%).

  24. Mu-Rong Chao, Domniki Fragou, Panos Zanos and Chiung-Wen Hu, Alexis Bailey, Sofia Kouidou, Leda Kovatsi. Epigenetically modified nucleotides in chronic heroin and cocaine treated mice. Toxicology Letters, 2014, 229, 451-457. (SCI; Impact factor = 3.166, Ranking in Toxicology = 29/94 = 30.8%).

  25. Mu-Rong Chao, Chiung-Wen Hu and Jian-Lian Chen. Fluorescent turn-on detection of cysteine using a molecularly imprinted polyacrylate linked to allylthiol-capped CdTe quantum dots. Microchim Acta, 2014, 181, 1085-1091. (SCI; Impact factor = 5.705, Ranking in Chemistry, analytical = 6/80 = 7.5%).

  26. Ching-Chiang Lin, Hsiu-Hua Huang, Chiung-Wen Hu, Bai-Hsiun Chen, Inn-Wen Chong, Yu-Ying Chao and Yeou-Lih Huang. Trace elements, oxidative stress and glycemic control in young people with type 1 diabetes mellitus. Journal of Trace Elements in Medicine and Biology, 2014, 28, 18-22. (SCI; Impact factor = 3.755, Ranking in Biochemistry & Molecular Biology = 88/292 = 30.1%).

  27. Chiung-Wen Hu, Yu-Wen Hsu, Jian-Lian Chen, Lai-Man Tam and Mu-Rong Chao. Direct analysis of tobacco-specific nitrosamine NNK and its metabolite NNAL in human urine by LC-MS/MS: evidence of linkage to methylated DNA lesions. Archives of Toxicology, 2014, 88, 291-299. (SCI; Impact factor = 5.728, Ranking in Toxicology = 7/94 = 7.4%).

  28. Mu-Rong Chao, Pavel Rossner Jr., Siamak Haghdoost, Hueiwang Anna Jeng and Chiung-Wen Hu. Nucleic Acid Oxidation in Human Health and Disease. Oxidative Medicine and Cellular Longevity, 2013, 2013, 368651. (SCI; Impact factor = 4.936, Ranking in Cell Biology = 52/190 = 27.4%).

  29. Ching-Hsuan Hu, Nai-Jen Chang, Cheng-Hung Lin, Chiung-Wen Hu*(Co-corresponding Author) and Chih-Hung Lin. Urinary excretion of oxidative damage markers in a rat model of vascularized composite allotransplantation. Plastic and Reconstructive Surgery, 2013, 132, 530e. (SCI; Impact factor = 3.475, Ranking in Surgery = 30/200 = 15%).

  30. Chiung-Wen Hu, Huei Lee, Jian-Lian Chen, Yi-Jie Li and Mu-Rong Chao. Optimization of global DNA methylation measurement by LC-MS/MS and its application in lung cancer patients. Analytical and Bioanalytical Chemistry, 2013, 405, 8859-8869. (SCI; Impact factor = 3.307, Ranking in Chemistry, analytical = 15/80 = 18.8%).

  31. Lars Barregård, Peter Moller, Trine Henriksen, Vilas Mistry, Gudrun Koppen, Pavel Rossner, Radim Sram, Allan Weimann, Henrik Poulsen, Robert Nataf, Roberta Andreolli, Paola Manini, Timothy H Marczylo, Patricia Lam, Mark Dennis Evans, Hiroshi Kasai, Kazuaki Kawai, Yun-Shan Li, Kazuo Sakai, Raj Singh, Friederike Teichert, Peter Farmer, Rafal Rozalski, Daniel Gackowski, Agnieszka Siomek, Guillermo Saez, Concha Cerda, Karin Broberg, Christian Lund, Mohammad Hossain, Siamak Haghdoost, Chiung-Wen Hu, Mu-Rong Chao, Kuen-Yuh Wu, Nilufer Senduran, Hilmi Orhan, Raymond J Smith, Regina Santella, Yali Su, Czarina Cortez, Susan Yeh, Ryszard Olinski, Steffen Loft and Marcus Stanley Cooke. Human and methodological sources of variability in the measurement of urinary 8-oxo-7,8-dihydro-2’-deoxyguanosine. Antioxidants & Redox Signaling, 2013, 18, 2377-2391. (SCI; Impact factor = 6.53, Ranking in Endocrinology & Metabolism = 12/143 = 8.4%).

B.   專利

1.          趙木榮，胡瓊文，張惠華，王建仁。尿液中基因氧化傷害產物之自動化檢測方法。中華民國專利號碼發明第I317425號，公告日期：98/11/21。

2.          Jin-Ming Chen, Chien-Te Hsieh, Yue-Hao Huang, Rong-Rong Kuo, Yu-Run Lin, Chiung-Wen Hu, Mu-Rong Chao, Kuen-Yuh Wu. SOLID-PHASE NANO EXTRACTION DEVICE. United States Patent 7404932, issued on July 29, 2008.

3.          陳金銘，謝建德，黃裕豪，郭蓉蓉，林育潤，胡瓊文，趙木榮，吳焜裕。固相微量萃取裝置。中華民國專利號碼發明第I253352號，公告日期：95/04/21。