何應瑞 副教授

 中山醫學大學   

 心理學系

　

Ying-Jui Ho Ph.D.

Associate Professor

Division of Clinical Psychology

School of Psychology 

Chung Shan Medical University

研究室介紹 

(Lab Introduction)

實驗室照片集

(Lab Photo)

國際交流成果

(International Activity)

[2006], [2007]

學經歷資料

　

博 士: 台灣大學醫學院  生理學研究所

          主修:  精神疾病之神經機轉

碩 士: 國防醫學院  生理學研究所

          主修: 精神病藥物對腦部神經化學訊遞之影響

學 士: 高雄醫學院  藥學系  

  1. 中山醫學大學附設醫院  醫學研究部 顧問  (2009/09/01- )

  2. 台灣神經調節學會  理事 (2007/12-- )

  3. 德國 海德堡大學 Central Institute of Mental Health, Visiting Fellow

  4. 中山醫學大學  課外活動組 組長 (2006/3--2008/2)

  5. 德國 Philipps University of Marburg, Department of Experimental and Physiological Psychology, Visiting Fellow

  6. 扶輪教育基金受獎人聯誼會 04-05年中區分會長；08-10總會副會長

   

　

以動物實驗研究人類之疾病--刊登於德國報紙 2001年

2007年率領中山醫學大學傑出社團領導人赴德國Marburg大學交流---刊登於德國報紙 (2007.07.19)

2008年率領中山醫學大學傑出社團領導人赴德國Marburg大學交流

　

講授課程  課程綱要

（請按課程名稱顯示教材PDF檔）

l         人體生理學

l         神經科學

l         生理心理學（神經解剖與生理）

l         神經生理學

l         神經與行為科學研究法

 

l         藥物濫用與防治 (通識:毒品的世界)

l         腦傷與行為 (通識:大腦與人類行為)  

l         心理藥物學

　

研究特色

研究主題：探討神經精神疾病（特別是巴金森氏症、焦慮症及憂鬱症等）與精神藥物的神經機轉，也包括毒品的神經毒性。研究中以微透析技術（microdialysis）、放射線受體標定技術（receptor binding）、腦部冷凍切片（brain slice）、高壓液相層析（HPLC）、免疫組織化學染色（IHC）及Western blot、ELISA蛋白質測定法測量神經化學物質及神經功能之變化。

Research interest: Exploring the mechanism of neuropsychological disorders, such as, Parkinson’s disease, anxiety, and depression, as well as the topics on psychopharmacology and addiction

神經行為實驗室：運用高腳十字迷宮（elevated plus-maze）、開放空間行為測定儀（open field）、往復式觀察箱（shuttle box）、forced swim test等儀器輔助測定動物之行為表現，例如運動、學習、記憶、焦慮、憂鬱及攻擊等行為，並結合生化及分子生物學的技術，從分子層面深入探討神經、免疫與心理功能。

研究目標：進一步釐清神經精神疾病的機轉，以期開發更有效的醫療方法。

　

近年應用D-cycloserine於治療巴金森氏症神經退化與失智症狀的研究成果

吾人之研究團隊近年來專注投入從事PD相關主題之研究工作，釐清麩胺酸神經系統、NMDA受體與發炎性細胞激素在PD之病理生理角色[1-3]，並且探討DCS對動物行為[4]及神經功能[5]之影響，已經確立以MPTP注射到大鼠中腦黑質體除了會破壞多巴胺神經系統，導致動物出現運動功能障礙之PD動物模式[6]，也會引起腦部黑質體、紋狀體及海馬回內之微膠細胞活化及發炎性細胞激素濃度增加之現象[7]，而且會造成海馬回神經細胞死亡，同時動物會出現情緒焦慮、學習障礙與認知功能缺陷等PDD的動物模式[8-10]。本研究室首先證實DCS（30及100 mg/kg/day, i.p.）可以改善MPTP處理所誘發的PD動物之運動、焦慮及認知功能[9]，而且DCS在劑量為10 mg/kg/day時，可以使MPTP處理之動物恢復情境記憶之功能，使動物可以整合事件之what、where、when等元素，執行相當高階的認知功能，更令人興奮的發現是：DCS可以降低PD動物腦部微膠細胞活化與神經退化現象[8-10]。但是很意外地，當DCS劑量為30 mg/kg/day時，卻無上述行為與神經學之效果[10]，顯示DCS之「劑量-反應」關係可能並非單純的線性關係，這一點在臨床應用上值得注意。

 

Recent studies: Appling D-cycloserine on Neurodegeneration and Dementia in Parkinson’s Disease

We have recently engaged in the research on Parkinson’s disease (PD)-related topics to clarify the role of glutamatergic system, NMDA receptors, and inflammatory cytokines in pathophysiology of PD [1-3]. Moreover, the effects of D-cycloserine (DCS) on animal behavior [4] and neurological functions [5] have also been probed into. So far, the MPTP injected into the substantia nigra of rats has been known not only to destroy the dopaminergic system and cause motor dysfunction in PD animal model [6] but also elicit microglial activation and increased levels of inflammatory cytokines in the substantia nigra, striatum, and hippocampus [7]. In addition, MPTP causes neuronal cell death in the hippocampus, increase of anxiety level, learning disabilities, and cognitive dysfunction, which is thus suggested as an animal model of PDD [8-10]. Our laboratory is the first to have proven that DCS (30 and 100 mg/kg/day, i.p.) can improve locomotion, anxiety, and cognitive function in MPTP-induced PD animal model [11] and that DCS at dosage of 10 mg/kg/day ensure animals under MPTP treatment restore their episodic-like memory, a complicate cognitive function that integrates such elements as what, where, and when. Amazingly, findings also show that DCS reduces microglial activation and neurodegeneration in the brain of PD anima [8-10]. But surprisingly noted that when the DCS doses are at 30mg/kg/day, the above neurobehavioral effects are not observed [10]. Thus, the dose-response of DCS may not be linear, which is noteworthy in clinical applications.

 

References

[1]           何應瑞, 巫錫霖, 王文甫, 施曉雅, 黃耀庭. 巴金森氏症患者的幻覺及其可能的神經心理機轉. 台灣醫學 2009; 14: in press.

[2]           黃秋谷, 王慶福, 徐文鈺, 何應瑞, 黃耀庭, 賴德仁. 影響神經功能及情感疾病之發炎物質：心理神經免疫學之基礎. 臨床醫學 2006; 58: 51-56.

[3]           黃秋谷, 王慶福, 徐文鈺, 賴德仁, 何應瑞. 麩胺酸神經系統NMDA受體在精神分裂症之角色：作用在甘胺酸結合位之藥物所得的證據. 臨床醫學 2005; 55: 253-258.

[4]           杜偉廷, 曾鼎, 王安莉, 鍾宛玲林俊成, 許立松, 徐文鈺, 王慶福, 何應瑞. NMDA受體在D-cycloserine對焦慮行為作用之角色. 台灣醫學 2005; 9: 173-179.

[5]           Wu SL, LS Hsu, WT Tu, WF Wang, YT Huang, CR Pawlak, YJ Ho. Effects of D-cycloserine on the behavior and ERK activity in the amygdala: role of individual anxiety levels. Behav Brain Res 2008; 187: 246-253.

[6]           Sy HN, SL Wu, WF Wang, CH Chen, YT Huang, YM Liou, CS Chiou, CR Pawlak, YJ Ho. MPTP-induced dopaminergic degeneration and deficits in object recognition in rats are accompanied by neuroinflammation in the hippocampus. Pharmacol Biochem and Behav 2010; in press.

[7]           Wang WF, SL Wu, YM Liou, AL Wang, CR Pawlak, YJ Ho. MPTP lesion causes neuroinflammation and deficits in object recognition in Wistar rats. Behav Neurosci 2009; 123: 1261-1270.

[8]           王安莉. D-cycloserine對MPTP處理後之Wistar大鼠的類情境記憶缺陷之影響. 生命科學系, 國立中興大學. 台中. 碩士論文. 指導教授：劉英明、何應瑞. 2009.

[9]           陳昶豪. Dcycloserine對MPTP所誘發之細胞介白素-2與行為缺陷之效果：麩胺酸神經系統在巴金森氏症誘發失智症的可能角色. 醫學研究所, 中山醫學大學. 台中. 碩士論文. 指導教授：黃淑桂、何應瑞. 2007.

[10]         Wang AL, YM Liou, CR Pawlak, YJ Ho. Involvement of NMDA receptors in both MPTP-induced neuroinflammation and deficits in episodic-like memory in Wistar rats. Behav Brain Res 208: 38-46, 2010

[11]         Chen CH, SI Wu, PJ Tsai, AL Wang, YT Lee, SY Tai, CJ Hsieh, YT Huang, WF Wang, SL Wu, SK Huang, YJ Ho. Changes of cognitive behavior and central proinflammatory cytokine in MPTP-induced animal model of Parkinson’s disease: role of the NMDA receptor The 22nd Joint Annual Conference of Biomedical Science. Taipei, Taiwan, ROC; 2007.

　

研究現況與未來發展

   近年主持之研究計畫主題包括：

1.「D-cycloserine應用於治療巴金森氏症失智的療效」

2.「D-cycloserine 對憂鬱症動物模式其壓力行為之影響：NMDA受體的可能角色」

3.「基側杏仁核調節壓力環境中行為及神經活性之角色：以嗅球切除之大鼠為憂鬱症模式」

4.「山藥對停經動物焦慮及憂鬱行為之影響：神經免疫功能之角色」

5.「山藥對切除卵巢之雌鼠的骨密度及機械特性之功效」

6.「多巴胺轉運蛋白和NMDA受體遺傳基因多型性與巴金森氏病之失智症易感受性研究」

7.「以動物模式探討麩胺酸神經系統在巴金森氏症所引發神經免疫反應之角色」

8.「不可逃避之壓力對大鼠神經免疫功能的影響」

規劃中之研究主題將更深入探討淮山等中藥成分對麩胺酸（glutamate）神經系統、精神疾病及神經毒性之角色，藥物濫用者神經系統功能之變化也是有興趣的主題。歡迎有興趣的同學及學者一起合作，共同進行精神疾病及神經行為領域之研究。

　

專題研究計畫  

計畫名稱

補助機構

/擔任工作

起迄

年月
以動物為模式探討麩胺酸神經系統在MPTP誘發神經行為功能異常之角色 Exploring the role of glutamatergic system in MPTP-induced neuro-behavioral deficits: an animal study  [CSH-2010-C-020]

中山院內計畫/共同主持人

 99/01/01 ~ 99/12/31

探討麩胺酸神經系統在MPTP所誘發之神經發炎及行為缺陷的角色：嘗試建立巴金森氏症失智的動物模式

Studying the role of glutamatergic systems on MPTP-induced neuronal inflammation and behavioral deficits: establishing an animal model for dementia in Parkinson’s disease  [NSC98-2410-H-040-003-]

國科會

/主持人

98/08/01 - 99/07/31

一個新的環境污染議題：十溴苯醚影響後代發育、神經行為及腦部蛋白質體學之探討（3年計畫）[NSC 97-2221-E-127 -003 -MY3]

國科會

/共同主持人

 97.08.01- 100.07.31

Studying the effects of amantadine on episodic-like memory: possible role in Parkinson’s disease dementia [97CCH-CSMU-14]

中山醫學大學彰化基督教醫院/主持人

97.08.1- 98.07.31

心理壓力對於動物面對急性生理壓力時腦內細胞激素IL-2之影響

Role of psychological stress in the acute physical stress-induced changes of IL-2 in the brain

彰化基督教醫院/共同主持人

97.01.01- 97.12.31

Evaluating the effects of amantadine on the neuroimmunological function in Parkinson’s disease: role of glutamatergic system in the degenerative dementia

評估amantadine對巴金森氏症神經免疫功能之影響：麩胺酸神經系統在神經退化性失智症之角色  (NSC 96-2320-B-040-019)

國科會

/主持人

96.08.01- 97.07.31

Effects of inescapable stress on the neuroimmunological function: role of dopaminergic system and brain cytokines in depression animal model [計畫編號92521]

不可逃避之壓力對神經免疫功能的影響：多巴胺神經系統與腦內細胞激素在憂鬱症動物模式之角色

彰化基督教醫院/共同主持人

96.01.01- 96.12.31

台德雙方合作研究計畫人員交流計畫PPP DAAD/NSC Project Based Personnel Exchange Program 計畫編號：0950042882P；核定編號：96-2911-I-040-00

國科會

/主持人

96.01.01- 96.12.31

 
Studying the effects of diosgenin on the neuroimmunological function of menopausal rats: also evaluating the response on the cell level
探討薯蕷皂甘對停經大鼠之神經免疫功能的影響：一併探討細胞層面之效果
(NSC 95-2320-B-040-009)

國科會

/主持人

95.08.01- 96.07.31

台德雙方合作研究計畫人員交流計畫PPP. DAAD/NSC Project Based Personnel Exchange Program. 計畫編號：0940042882；核定編號：95-2911-I-040-001

國科會

/主持人

95.01.01- 96.12.31

多巴胺轉運蛋白和NMDA受體遺傳基因多型性與巴金森氏病之失智症易感受性研究【子計畫A】；並以動物模式探討麩胺酸神經系統在巴金森氏症所引發神經免疫反應之角色【子計畫B】(Chang-Hua Christian Hospital, CCH grant 93118)

彰化基督教醫院/共同主持人

95.01.01- 96.12.31

Effects of inescapable stress on the neuroimmunological function of rats: preliminary study

不可逃避之壓力對大鼠神經免疫功能的影響：初探(C950006)

彰化基督教醫院/共同主持人

95.01.01- 95.12.31

Study on the behavioral and psychoneuroimmunological effects of dioscorea in menopausal rats: also evaluating the responses on the cell level

探討山藥對停經大鼠的行為及心理神經免疫功能之影響：一併探討細胞層面之效果 (NSC 94-2320-B-040-019)

國科會

/主持人

94.08.01- 95.07.31

薯蕷皂素對停經動物憂鬱行為與學習功能的影響：賀爾蒙濃度之角色 (94-2815-C-040-028-B)

國科會大專學生研究計畫

/指導教授

94.07.01- 95.02.28

Effects of dioscorea on bone density and mechanical properties in the ovariectomized rats

山藥對切除卵巢之雌鼠的骨密度及機械特性之功效 (DOH94-TD-F-113-021)

衛生署

/協同主持人

94.01.01- 94.12.31

 
The role of anxiety level in the effects of D-cycloserine on the stress response and mitogen-activated protein kinase (NSC 93-2320-B-040-015)

國科會

/主持人

93.08.01- 94.07.31

 
A study on the effects of dietary supplement of dioscorea on the anxiety and depression in ovariectomized rats
探討飲食中補充山藥對卵巢切除之動物焦慮及憂鬱行為的影響 (CSMU 93-OM-B-001)

中山醫學大學

/共同主持人

93.08.01- 94.06.30

 
Role of basolateral amygdala in stress-induced behavioral and neuronal responses: depression animal model of olfactory bulbectomized rats
(NSC 92-2320-B-040-022)

國科會

/主持人

92.08.01- 93.07.31

 
Effects of D-cycloserine on the stress response and mitogen-activated protein kinase: role of anxiety level (CSMU 92-OM-B-006)

中山醫學大學

/共同主持人

92.10.01- 93.09.30

 
Effects of D-cycloserine on the stress response in depression animal model: role of NMDA receptors (CSMU 91-OM-B-021)

中山醫學大學

/主持人

91.10.01- 92.09.30

 

學術著作 (Publication)

(A) 英文著作 (Referred Paper)

  1. Sy HN, SL Wu, WF Wang, CH Chen, YT Huang, YM Liou, CS Chiou, CR Pawlak, YJ Ho*. MPTP-induced dopaminergic degeneration and deficits in object recognition in rats are accompanied by neuroinflammation in the hippocampus. Pharmacol Biochem and Behav 95: 158-65, 2010. (SCI). PDF

  2. Wang AL, YM Liou, CR Pawlak, YJ Ho*. Involvement of NMDA receptors in both MPTP-induced neuroinflammation and deficits in episodic-like memory in Wistar rats. Behav Brain Res 208: 38-46, 2010 (SCI), PDF

  3. Wang WF#, SL Wu#, YM Liou, AL Wang, CR Pawlak, YJ Ho*. MPTP lesion causes neuroinflammation and deficits in object recognition in Wistar rats. Behavioral Neuroscience 123(6): 1261-70, 2009. (SCI), PDF

  4. Karrenbauer BD, YJ Ho, V Ludwig, J Löhn, R Spanagel, RKW Schwarting, CR Pawlak. Time-dependent effects of striatal interleukin-2 on open field behaviour in rats. Journal of Neuroimmunology. 208: 10-18, 2009. (SCI), PDF

  5. Bauhofer A, YJ Ho, A Schmitt, M Köster, RKW Schwarting, CR Pawlak. Individual behavioral differences in recovery from abdominal sepsis in rats. Inflammation Res 58:1-9, 2009. (SCI), PDF

  6. Lee SD, WW Kuo, YJ Ho, AC Lin, CH Tsai, HF Wang, CH Kuo, AL Yang, CY Huang, JM Hwang. Cardiac Fas receptor-dependent and mitochondrial dependent apoptosis in ovariectomized rats. Maturitas 61:268-77, 2008. (SCI), PDF

  7. Chiang CY, KY Yeh, SF Lin, H Hsuchou, MY Tai, YJ Ho *, YF Tsai *. Effects of alcohol on the mouse-killing behavior of olfactory bulbectomized rats. Chinese J Physiol 51(6): 408-13, 2008. (SCI), PDF

  8. Chen JH, JSS Wu, HC Lin, SL Wu , WF Wang, SK Huang, YJ Ho*. Dioscorea improves the morphometric and mechanical properties of bone in ovariectomized rats. J Sci Food Agr 88: 2700-06, Oct. 7. 2008. (SCI), PDF

  9. Pawlak CR*, YJ Ho*, R. K.W. Schwarting*. Animal models of human psychopathology based on individual differences in novelty-seeking and anxiety. Neuroscience & Biobehavioral Reviews 32: 1544-68, 2008. (SCI), PDF

  10. Lee YT, WF Wang, CW Cheng, SL Wu, CR Pawlak, YJ Ho*. Effects of escapable and inescapable stressors on behavior and interleukin-2 in the brain. Neuroreport 19(12): 1243-47, Aug. 6. 2008. (SCI), PDF 

  11. Hsieh YS, SF Yang, SC Chu, YJ Ho, CS Kuo, DY Kuo. Transcriptional interruption of cAMP response element binding protein modulates superoxide dismutase and neuropeptide Y-mediated feeding behavior in freely moving rats. J Neurochem 105: 1438-1449, May, 2008. (SCI)., PDF 

  12. Wu SL, LS Hsu, WT Tu, WF Wang, YT Huang, CR Pawlak*, YJ Ho*. Effects of D-cycloserine on the behavior and ERK activity in the amygdala: Role of individual anxiety levels. Behav Brain Res 187(2): 246-53, Mar.5. 2008.  (SCI), PDF

  13. Ho YJ*, WY Hsu, CF Wang, T Tseng, CW Cheng, YC Hung, CC Hsu, MD Kao, YF Tsai. Psychoimmunological Effects of Dioscorea in the Ovariectomized Rats: Role of Anxiety Level. Annals of General Psychiatry 6:21, Aug 10, 2007.  【獲頒亞理斯多德研究獎Aristotle Research Award; 頒發單位：The International Society on Brain and Behaviour：http://www.psychiatry.gr/main_brain2_eng.html】, PDF

  14. WF Wang, T Tseng, WY Hsu, CF Wang, CC Hsu, YJ Ho*. Effects of Apomorphine on the Expression of Learned Helplessness Behavior. Chinese J Physiol 50(2): 63-68, April 30, 2007. (SCI), PDF

  15. Chen LM, WW Kuo, JJ Yang, SG Wang, YL Yeh, FJ Tsai, YJ Ho, MH Chang, CY Huang, SD Lee. Eccentric Cardiac Hypertrophy was Induced by Long-term Intermittent Hypoxia. Exp Physiol Mar, 92(2):409-16, 2007. (SCI), PDF

  16. Ho YJ*, LS Hsu, CF Wang, WY Hsu, TJ Lai, CC Hsu, YF Tsai. Behavioral effects of D-cycloserine in rats: the role of anxiety level. Brain Res 1043: 179-185, May. 2005. (SCI), PDF

  17. Ho YJ, KH Chen, MY Tai, YF Tsai. MK-801 Suppresses Muricidal Behavior But Not Locomotion in Olfactory Bulbectomized Rats: Involvement of NMDA Receptors. Pharmacol Biochem Behav 77:641-646, 2004. (SCI), PDF

  18. Ho YJ, H Hsuchou, HA Shui, MY Tai, KH Chen, YF Tsai: Effects of Desipramine and MK-801 on components of muricidal behavior in olfactory bulbectomized rats: an application of incisor-cutting animal model. Neurosci Res Comm 34(3): 136-43, 2004.  (SCI), PDF

  19. Ho YJ, CR Pawlak, LH Ku, Schwarting RKW: Acute and long-term consequences of single MDMA administration in relation to individual anxiety levels in the rat. Behav Brain Res 149:135-144, 2004. (SCI), PDF

  20. Pawlak CR, YJ Ho, RKW Schwarting, A Bauhofer: Relationship between striatal interleukin-2 mRNA levels and anxiety in the rat. Neurosci Lett 341:205-208, 2003. (SCI), PDF

  21. Ho YJ, J Eichendorff, RKW Schwarting: Individual response profiles of male Wistar rats in animal models of anxiety and depression. Behav Brain Res 136:1-12, 2002. (SCI), PDF

  22. Hsuchou H, YJ Ho, HA Shui, MY Tai, KH Chen, YF Tsai: Effects of incisor cutting on olfactory bulbectomy-induced muricidal behavior in rats. Physiol and Behav 76 (4-5): 669-75, 2002. (SCI), PDF

  23. Ho YJ, TM Liu, MY Tai, CS Wong, YF Tsai: Effects of olfactory bulbectomy on the density of NMDA receptors in rat’s brain: [3H] MK-801 binding assay. Brain Res 900:214-218, 2001. (SCI), PDF

  24. Ho YJ, YC Chang, TM Liu, MY Tai, CS Wong, YF Tsai: Striatal glutamate release during novelty exposure-induced hyperactivity in olfactory bulbectomized rats. Neurosci Lett 287 (2):117-120, 2000. (SCI), PDF 

　

(B) 中文著作 （in Chinese with English abstract）

  1. 何應瑞*、巫錫霖、王文甫、施曉雅、黃耀庭。巴金森氏症患者的幻覺及其可能的神經心理機轉。（台灣醫學，2010 in press）。 Ying-Jui Ho*, Shey-Lin Wu*, Wen-Fu Wang, Hiu-Ngar Sy, Yao-Ting Huang. Hallucinations in Parkinson’s disease: the possible neuropsychological mechanisms, Formosan J Medicine 2009 (in press).（本論文承黃國洲先生繪製插圖，特別致上謝意）

  2. 何應瑞*、巫錫霖、王文甫、黃耀庭、鄭鈞文。麩胺酸神經系統與神經免疫功能在巴金森氏症失智的可能角色。台灣醫學 13(1): 100-06, Jan. 1st. 2009。【Ying-Jui Ho*, Shey-Lin Wu, Wen-Fu Wang, Yao-Ting Huang, Chun-Wen Cheng. Role of glutamatergic and neuroimmunological function in the dementia in Parkinson’s disease. Formosan J Medicine 13(1): 100-06, Jan. 1st. 2009】PDF

  3. 王慶福、游顯妹、王郁茗、何應瑞、曾淑梅。配合生理回饋之放鬆訓練對重症加護病房護理人員焦慮反應之影響效果（The effects of biofeedback-assisted relaxation on nursing staffs with anxiety reaction in ICU, Chung Shan Medical Journal）。中山醫學雜誌，18(2): 241-53, Dec. 2007。

  4. 王慶福、鍾麗珍、王郁茗、何應瑞、賴德仁。生理回饋訓練與放鬆訓練對大學生焦慮與憂鬱反應之影響效果（Effect of biofeedback training and relaxation training on anxiety and depressive reactions of college students, Chung Shan Medical Journal）。中山醫學雜誌，18(2): 255-70, Dec. 2007。

  5. 黃秋谷、何應瑞*。搖頭丸，危險的急性中毒與棘手的慢性中毒。臨床藥學雜誌 10(2): 49-62, 2002. (CK Huang, YJ Ho*. “Ecstasy” 3,4 Methylenedioxymethamphetamine: dangerous acute-effects and long-term toxicity. Clinical Pharmacology 10(2): 49-62, 2002.)

  6. 何應瑞*、蔡元奮。麩胺酸神經系統在憂鬱症中可能的角色：以嗅球被切除之大鼠為動物模式所得的證據。台灣精神醫學雜誌  19(1): 5-18, 2005. (YJ Ho*, YF Tsai. Possible Role of Glutamatergic System in Depression: Evidence from Animal Model of Olfactory Bulbectomized Rats. Taiwanese J Psych 19(1): 5-18, 2005.)

  7.  黃秋谷，王慶福，徐文鈺，賴德仁，何應瑞*。麩胺酸神經系統NMDA受體在精神分裂症之角色：作用在甘胺酸結合位之藥物所得的證據。臨床醫學月刊  55(4): 253-258,   (Huang CK, CF Wang, WY Hsu, TJ Lai, YJ Ho*. Role of glutamatergic NMDA receptor in schizophrenia: evidence from drugs acting at the glycine binding site. Clinical Medicine 55(4): 253-258, Apr. 2005.)  

  8. 杜瑋庭、曾鼎、王安莉、鍾宛玲、林俊成、許立松、徐文鈺、王慶福、何應瑞*。NMDA受體在D-cycloserine對焦慮行為作用之角色。台灣醫學 9(2): 173-179, Mar. 2005.      (Tu WT, T Tseng, AL Wang, WL Chung, CC Lin, LS Hsu, WY Hsu, CF Wang, YJ Ho. Effects of D-cycloserine on anxiety behavior: role of NMDA receptor. Formosan Journal of Medicine 9(2): 173-197, 2005. (in Chinese with English abstract))

  9. 黃秋谷、王慶福、徐文鈺、黃耀庭、賴德仁、何應瑞*。影響神經功能並參與情感疾病之發炎物質：心理神經免疫學之基礎。臨床醫學月刊 58(1):51-56, 2006。(Huang CK, CF Wang, WY Hsu, YT Huang, TJ Lai, YJ Ho*. Inflammatory substances affecting neuronal function and affective disorders: fundamentals of psychoneuroimmunology. Clinical Medicine 58(1):51-56, 2006. [NSC 93-2320-B-040-015; CSMU 93-OM-B-001; CSMU 93-OM-A-011] (in Chinese with English abstract)

  10. 何應瑞。山藥，植物性的賀爾蒙。常春月刊  164:90-93, 1996。 (Ho YJ. Dioscorea, Phytohormone. Evergreen 164:90-93, 1996. (in Chinese with English abstract)

　

　

(C) 投稿中 （Submitted）

    1.          Wen-Fu Wang, Shey-Lin Wu, Ying-Ming Liou, Cornelius Rainer Pawlak, Ying-Jui Ho*. Effects of MPTP lesion on behavior and neuroinflammation in Wistar rats: a possible animal model of Parkinson’s disease dementia (submitted to J Neuro immu, 09.03.23) [(NSC 96-2320-B-040-019, Chang-Hua Christian Hospital (CCH grant 93118 and 92137)]

    2.          Hiu-Ngar Sy1#, Shey-Lin Wu1, 2#, Wen-Fu Wang1, Chang-Hao Chen3, Yao-Ting Huang1, Ying-Ming Liou4, Chien-Shun Chiou5, Cornelius Rainer Pawlak6, 7*, Ying-Jui Ho*. MPTP-induced dopaminergic degeneration and deficits in object recognition are accompanied with neuroinflammation in the hippocampus. Pharmacol Biochem Behav [(NSC 96-2320-B-040-019; PPP 0950042882P, CCH grant 93118 and 92137, 097-CCH-CSMU-14) ]

    3.         Cornelius R. Pawlak, Britta D. Karrenbauer, Peggy Schneider, Ying–Jui Ho. The elevated plus–maze test: Role of individual anxiety-related behaviour. (submitted to: Emotion review, 090305)

　

 

(D) 會議摘要(超過70篇摘要) (Conference Abstract, more than 70 abstracts)   　 

1.            Ho SC, KJ Huang, YJ Ho*. Role of NMDA receptors on animal model of Parkinson’s disease dementia. Brain circuits – from receptors to network dynamics, Research workshop of the Israel science foundation. Ein-gedi, Israel, Jan. 31 – Feb. 4, 2010.

2.            Huang GJ, SC Ho, SL Gu, CW Wang, CK Lai, YJ Ho*. Role of NMDA receptors on mice model of Parkinson’s disease: effects of D-cycloserine and amantadine. Brain circuits – from receptors to network dynamics, Research workshop of the Israel science foundation. Ein-gedi, Israel, Jan. 31 – Feb. 4, 2010.

3.            Wu FY, GJ Huang, WN Huang, YJ Ho*. Visuo-spatial Attention in MPTP-induced Animal Model of Parkinson’s Disease: Testing in The 5-arm maze. Brain circuits – from receptors to network dynamics, Research workshop of the Israel science foundation. Ein-gedi, Israel, Jan. 31 – Feb. 4, 2010.

4.            Wang AL, WN Huang, SC Ho, KJ Huang, YM Liou, YJ Ho*. Effects of D-cycloserine on MPTP-induced neuroinflammation and deficits in episodic-like memory in Wistar rats. (oral present). (邀請演講) Taiwanese Psychology Association 48th Conference, Sep. 26-27, 2009, Taipei.

5.            Huang GJ, CK Lai, SL Gu, CW Wang, WN Huang, SC Ho, MJ Jhang, SH Huang, YJ Ho*. Effects of D-cycloserine and amantadine on the behavior in MPTP-induced Parkinson’s disease mice model. Taiwanese Psychology Association 48th Conference, Sep. 26-27, 2009, Taipei.

6.            Wang CW, CK Lai, SL Gu, GJ Huang, WN Huang, SC Ho, MJ Jhang, SH Huang, YJ Ho*. Biphasic effects of amantadine on the emotional and recognition behavior in normal and dopamine-depleted C57BL/6 mice. Taiwanese Psychology Association 48th Conference, Sep. 26-27, 2009, Taipei.

7.            Huang GJ, SC Ho, CK Lai, SL Gu, AL Wang, WT Hsu, YW Kuo, YF Lin, HL Chen*, YJ Ho*. Application of Two-trial Object Recognition Test in BALB/c Mice. Taiwanese Psychology Association 48th Conference, Sep. 26-27, 2009, Taipei.

8.            Kuo CCH (郭俊顯), SY Tai, KY Wong, YJ Ho. Effects of Dopamine Antagonists SCH23390 and Raclopride on Fixed Time Schedule  Responding of Rats. Taiwanese Psychology Association 48th Conference, Sep. 26-27, 2009, Taipei

9.            Wang AL, WN Huang, SC Ho, YM Liou, YJ Ho. Effects of D-cycloserine on MPTP-induced Neuroinflammation and Deficits in Episodic-like Memory in Wistar Rats. The 22nd Biennial Meeting of the ISN/APSN Joint Meeting, Aug. 23 - 28, 2009. BEXCO, Busan, South Korea.

10.         陳立瑋、張珊華、李俊賢、曾麗荷、何應瑞、許昺奇。出生前暴露PBDE-47對子代成鼠自發性行為、學習與記憶影響。（ Effects of Prenatal Exposure of PBDE-47 on Spontaneous Behavior, Learning and Memory in Adult Mice Offspring. The 5th Conference on Environmental Hormones and POPs）第五屆環境荷爾蒙及持久性有機污染物研討會。Jun. 4, 2009。台北，台灣。

11.         張珊華、曾麗荷、何應瑞、許昺奇、陳立瑋、邵韻如。新生期暴露十溴二苯醚對自發性行為影響之研就究。（Chang SH, LH Tseng, YJ Ho, PC Hsu, LW1 Chen, YR Shao. Effects of Neonatal Exposure to 2,2’,3,3’,4,4’,5,5’,6,6’-Decabrominated Diphenyl Ether on Spontaneous Behavior in Mice.）工業衛生暨環境職業醫學學術研討會。Apr. 25-26, 2009。台中台灣。

12.       陳立瑋、張珊華、李俊賢、曾麗荷、何應瑞、許昺奇。經胎盤暴露PBDE-47對子代雄性成鼠自發行為、學習與記憶之評估。（Chen LW, SH Chang, CH Lee, LH Tseng, YJ Ho, PC Hsu.Evaluation of Spontaneous Behavior, Learning and Memory in Adult Male Mice Prenatally Exposed to PBDE-47.）工業衛生暨環境職業醫學學術研討會。Apr. 25-26, 2009。台中台灣。

13.       Huang WN, YH Wu, CH Fan, SH Li, SC Ho, AL Wang, YJ Lee, TY Lin, YJ Ho*, MC Ho*.  Visuo-spatial Attention in MPTP-induced Animal Model of Parkinson’s Disease: Testing in The 5-arm maze. The 24th Joint Annual Conference of Biomedical Science, 29-30, Mar. Taipei, ROC, 2008.

14.         Wang AL, CH Fan, YH Wu, WN Huang, SC Ho, YJ Lee, YM Liou, YJ Ho*. Effects of D-cycloserine on MPTP-induced Deficits in Episodic-like Memory in Wistar Rats. The 24th Joint Annual Conference of Biomedical Science, 29-30, Mar. Taipei, ROC, 2008.CH Fan, JS Guo, KL Lin, YJ Ho*. Effects of D-cycloserine on MPTP-induced Inflammation and Microglial Activation. 台灣心理學會第47屆年會，台北。4-5 Oct, 2008.

15.         AL Wang, YH Wu, CH Fan, WN Huang, KN Tai, YJ Lee, SC Ho, YM Liou, YJ Ho*. Effects of D-cycloserine on MPTP-induced deficits in episodic-like memory in Wistar rats. 台灣心理學會第47屆年會，台北。4-5 Oct, 2008.

16.         Wang AL, CH Chen, YT Huang, SL Wu, WF Wang, YM Liou, CR Pawlak, YJ Ho*.(王安莉、陳昶豪、黃耀庭、巫錫霖、王文甫、劉英明、Cornelius Rainer Pawlak、何應瑞). A possible animal model of Parkinson’s disease dementia: MPTP-induced behavior and neuroinflammation in Wistar rats. 台灣心理學會第47屆年會，台北。4-5 Oct, 2008.

17.         Lee YT, AL Wang, YH Wu, CH Fan, CR Pawlak, YJ Ho*, Physical and psychological stressors differently affect the level of interleukin-2 in the brain. International Congress of Psychology, 2008, July 20-25, Berlin, Germany.  

18.         羅敏智、黃耀庭、王文甫、巫錫霖、何應瑞、吳照明、鄭鈞文。卵巢切除小鼠其Tumor necrosis factor -γ基因表現和行為焦慮之關連性研究 (T Man-Chi Lo, Yao-Ting Huang, Wen-Fu Wang, Shey-Lin Wu, Ying-Jui Ho, Chao-Ming Wu, Chun-Wen Cheng. The correlation between gene expression of tumor necrosis factor-α �nand anxiety behavior in ovariectomized rats). 2008神經醫學會，26-27 Apr. 2008，台南，台灣

19.         王安莉、陳昶豪、范淳惠、吳玉莟、黃玟儂、莊亭萱、謝佩君、戴廣南、何應瑞* (Wang AL, CH Chen, CH Fan, YH Wu, WN Huang, TS Jhuang, PC Hsieh, KN Tai, YJ Ho*)。Effects of D-cycloserine on the MPTP-induced Changes of Cytokines in the Brain. The 23rd Joint Annual Conference of Biomedical Science, 29-30, Mar. Taipei, ROC, 2008. 

20.         范淳惠、吳玉莟、王安莉、黃玟儂、莊亭萱、何應瑞* (CH Fan, YH Wu, AL Wang, WN Huang, TS Jhuang, YJ Ho*)。Role of Cytokines in the Emotional Behavior. The 23rd Joint Annual Conference of Biomedical Science, 29-30, Mar. Taipei, ROC, 2008.

21.         吳玉莟、范淳惠、王安莉、黃玟儂、莊亭萱、何應瑞* (YH Wu, CH Fan, AL Wang, WN Huang, TS Jhuang, YJ Ho*)。NMDA Receptor-mediated ERK Signaling is Involved in Emotional Behavior: Role of Anxiety Level。The 23rd Joint Annual Conference of Biomedical Science, 29-30, Mar. Taipei, ROC, 2008.

22.         Karrenbauer BD, RKW Schwarting, YJ Ho, CR Pawlak. Can cytokines in the striatum modulate motivational behavior in rats? 2007 Society for Neuroscience 37th Annual Meeting, November 3-7, 2007, San Diego, CA, USA.

23.         Karrenbauer BD, RKW Schwarting, V Ludwig, J Löhn, R Spanagel, YJ Ho, CR Pawlak. Proactive drug mechanisms do not play a role in acute and delayed effects of Interleukin-2 in the striatum on emotional behaviour in rats. 2007 Society for Neuroscience 37th Annual Meeting, November 3-7, 2007, San Diego, USA.

24.         巫錫霖、王文甫、黃耀庭、何應瑞、黃淑桂。D-cycloserine對於以MPTP誘發巴金森病動物模式認知功能異常的影響。2007年神經醫學聯合學術研討會。台灣，桃園林口。

25.         Chen CH, SI Wu, PJ Tsai, AL Wang, YT Lee, SY Tai, CJ Hsieh, YT Huang, WF Wang, SL Wu, SK Huang, YJ Ho*. Changes of cognitive behavior and central proinflammatory cytokine in MPTP-induced animal model of Parkinson’s disease: role of the NMDA receptor The 22nd Joint Annual Conference of Biomedical Science, Taipei, ROC, 2007.

26.         AL Wang, CH Chen, CH Fan, YH Wu, WN Huang, TS Jhuang, PC Hsieh, KN Tai, YJ Ho*. Effects of D-cycloserine on the MPTP-induced Changes of Cytokines in the Brain. The 22nd Joint Annual Conference of Biomedical Science, Taipei, ROC, 2007.

27.         Hsieh CJ, YT Lee, SY Tai, CH Chen, AL Wang, WT Tu, SY Wu, PC Tsai, YJ Ho*. Role of stress experience in the foot shock–induced changes of behavior and cytokine level in rat brain. The 8th Annual Conference of Neuroscience Society Taiwan (2006 International Symposium on Stroke Research), Taipei, ROC, 2006. 【獲頒 傑出海報獎】

28.         Chen CH, SY Wu, PJ Tsai, AL Wang, YT Lee, SY Tai, CJ Hsieh, YT Huang, WF Wang, SL Wu, SK Huang, YJ Ho*. Effects of D-cycloserine on the cognitive dysfunction in MPTP-induced Parkinson’s disease: in animal model. The 8th Annual Conference of Neuroscience Society Taiwan (2006 International Symposium on Stroke Research), Taipei, ROC, 2006.

29.     Wang AL, CH Chen, CJ Hsieh , YT Lee, PC Tsai, SY Tai, SY Wu, FL Chen, SS Huang, YJ Ho*. Establishing an animal model of vascular ring of the trachea in Wistar rats. The 8th Annual Conference of Neuroscience Society Taiwan (2006 International Symposium on Stroke Research), Taipei, ROC, 2006.

  

 

(E) 學位論文 (Thesis)

  1.  Ho YJ: Glutamatergic system in the amygdala and striatum is involved in the mouse-killing behavior and novelty exposure-induced hyperactivity in olfactory bulbectomized rats. 2002.

  2. Ho YJ: Effects of excitatory amino acid and antipsychotics, haloperidal and amperozide, on dopamine transmission in rat’s nucleus accumbens and striatum. 1994.  

 

(F) 專書 (Books)

    1.  王春美、何應瑞、施柯念、秦作威、高婷玉、溫小娟、葉睿毅、廖美華、滿庭芳、駱明潔、盧敏吉、顏惠芷。新編生理學。華格那企業有限公司，2004年，台中市。

    2. 吳莉玲、朱冠州、何應瑞。生理學精要。藝軒圖書出版社，2003年，台北市。(ISBN 9576167108)

    3. 吳莉玲、何應瑞。生理學精華。藝軒圖書出版社，2002年，台北市。(ISBN 9576166799)

　

(G) 其他 (Others)

 1. 何應瑞: 精神分裂症多巴胺假說的演進

2. 何應瑞: 生理心理學介紹

　

山藥與更年期相關研究著作 (Dioscorea & menopause topics)

1.Lee SD, WW Kuo, YJ Ho, AC Lin, CH Tsai, HF Wang, CH Kuo, AL Yang, CY Huang, JM Hwang. Cardiac Fas receptor-dependent and mitochondrial dependent apoptosis in ovariectomized rats. Maturitas 61:268-77, 2008. (SCI), PDF （停經後加速心肌細胞凋亡及心臟腫大可能因此導致心臟衰竭）

2.Chen JH, JSS Wu, HC Lin, SL Wu , WF Wang, SK Huang, YJ Ho*. Dioscorea improves the morphometric and mechanical properties of bone in ovariectomized rats. J Sci Food Agr 88: 2700-06, Oct. 7. 2008. (SCI), PDF （山藥改善停經後之骨質疏鬆，增加骨骼強度）

3.Ho YJ*, WY Hsu, CF Wang, T Tseng, CW Cheng, YC Hung, CC Hsu, MD Kao, YF Tsai. Psychoimmunological Effects of Dioscorea in the Ovariectomized Rats: Role of Anxiety Level. Annals of General Psychiatry 6:21, Aug 10, 2007.  【獲頒歐洲亞理斯多德研究獎Aristotle Research Award】, PDF （山藥降低停經後之焦慮與憂鬱，改善中樞神經免疫功能）

4.何應瑞*。山藥，植物性的賀爾蒙。常春月刊  164:90-93, 1996。 (Ho YJ. Dioscorea, Phytohormone. Evergreen 164:90-93, 1996.

　

聯絡方式 Contact

E-mail:

yjho@csmu.edu.tw

joshuayjho@yahoo.com.tw

　

　

TEL: +886-4-2473-0022 ext.11858或11853

FAX: +886-4-2324-8191

address: 台中市南區(402)建國北路一段110號

                中山醫學大學 心理學系

　

Dr. Ying-Jui, Ho

School of Psychology

Chung Shan Medical University

No. 110, Sec. 1, Chien-Kuo N. Rd.

Tai-Chung City 402, Taiwan, ROC