講授課程 

研究特色

研究主題：探討神經精神疾病（特別是巴金森氏症、焦慮症及憂鬱症等）與精神藥物的神經機轉，也包括毒品的神經毒性。研究中以微透析技術（microdialysis）、放射線受體標定技術（receptor binding）、腦部冷凍切片（brain slice）、高壓液相層析（HPLC）、免疫組織化學染色（IHC）及Western blot、ELISA蛋白質測定法測量神經化學物質及神經功能之變化。

Research interest: Exploring the mechanism of neuropsychological disorders, such as, Parkinson’s disease, anxiety, and depression, as well as the topics on psychopharmacology and addiction

神經行為實驗室：運用高腳十字迷宮（elevated plus-maze）、開放空間行為測定儀（open field）、往復式觀察箱（shuttle box）、forced swim test等儀器輔助測定動物之行為表現，例如運動、學習、記憶、焦慮、憂鬱及攻擊等行為，並結合生化及分子生物學的技術，從分子層面深入探討神經、免疫與心理功能。

研究目標：進一步釐清神經精神疾病的機轉，以期開發更有效的醫療方法。

近年應用D-cycloserine於治療巴金森氏症神經退化與失智症狀的研究成果

近年來從事巴金森氏症（PD）相關主題之研究工作，釐清麩胺酸神經系統、NMDA受體與發炎性細胞激素在PD之病理生理角色[1-3]，並且探討DCS對動物行為[4]及神經功能[5]之影響，已經確立以MPTP注射到大鼠中腦黑質體除了會破壞多巴胺神經系統，導致動物出現運動功能障礙之PD動物模式[6]，也會引起腦部黑質體、紋狀體及海馬回內之微膠細胞活化及發炎性細胞激素濃度增加之現象[7]，而且會造成海馬回神經細胞死亡，同時動物會出現情緒焦慮、學習障礙與認知功能缺陷等PDD的動物模式[8-10]。本研究室首先證實DCS（30及100 mg/kg/day, i.p.）可以改善MPTP處理所誘發的PD動物之運動、焦慮及認知功能[9]，而且DCS在劑量為10 mg/kg/day時，可以使MPTP處理之動物恢復情境記憶之功能，使動物可以整合事件之what、where、when等元素，執行相當高階的認知功能，更令人興奮的發現是：DCS可以降低PD動物腦部微膠細胞活化與神經退化現象[8-10]。但是很意外地，當DCS劑量為30 mg/kg/day時，卻無上述行為與神經學之效果[10]，顯示DCS之「劑量-反應」關係可能並非單純的線性關係，這一點在臨床應用上值得注意。

Recent studies: Appling D-cycloserine on Neurodegeneration and Dementia in Parkinson’s Disease

We have recently engaged in the research on Parkinson’s disease (PD)-related topics to clarify the role of glutamatergic system, NMDA receptors, and inflammatory cytokines in pathophysiology of PD [1-3]. Moreover, the effects of D-cycloserine (DCS) on animal behavior [4] and neurological functions [5] have also been probed into. So far, the MPTP injected into the substantia nigra of rats has been known not only to destroy the dopaminergic system and cause motor dysfunction in PD animal model [6] but also elicit microglial activation and increased levels of inflammatory cytokines in the substantia nigra, striatum, and hippocampus [7]. In addition, MPTP causes neuronal cell death in the hippocampus, increase of anxiety level, learning disabilities, and cognitive dysfunction, which is thus suggested as an animal model of PDD [8-10]. Our laboratory is the first to have proven that DCS (30 and 100 mg/kg/day, i.p.) can improve locomotion, anxiety, and cognitive function in MPTP-induced PD animal model [11] and that DCS at dosage of 10 mg/kg/day ensure animals under MPTP treatment restore their episodic-like memory, a complicate cognitive function that integrates such elements as what, where, and when. Amazingly, findings also show that DCS reduces microglial activation and neurodegeneration in the brain of PD anima [8-10]. But surprisingly noted that when the DCS doses are at 30mg/kg/day, the above neurobehavioral effects are not observed [10]. Thus, the dose-response of DCS may not be linear, which is noteworthy in clinical applications.

研究現況與未來發展

   近年主持之研究計畫主題包括：

1. 「Ceftriaxone治療巴金森氏症失智之療效」

2. 「D-cycloserine應用於治療巴金森氏症失智的療效」

3. 「D-cycloserine 對憂鬱症動物模式其壓力行為之影響：NMDA受體的可能角色」

4. 「基側杏仁核調節壓力環境中行為及神經活性之角色：以嗅球切除之大鼠為憂鬱症模式」

5. 「山藥對停經動物焦慮及憂鬱行為之影響：神經免疫功能之角色」

6. 「山藥對切除卵巢之雌鼠的骨密度及機械特性之功效」

7. 「多巴胺轉運蛋白和NMDA受體遺傳基因多型性與巴金森氏病之失智症易感受性研究」

8. 「以動物模式探討麩胺酸神經系統在巴金森氏症所引發神經免疫反應之角色」

9. 「不可逃避之壓力對大鼠神經免疫功能的影響」

規劃中之研究主題將更深入探討淮山等中藥成分對麩胺酸（glutamate）神經系統、精神疾病及神經毒性之角色，藥物濫用者神經系統功能之變化也是有興趣的主題。歡迎有興趣的同學及學者一起合作，共同進行精神疾病及神經行為領域之研究。

專題研究計畫  

Effects of inescapable stress on the neuroimmunological function: role of dopaminergic system and brain cytokines in depression animal model  [計畫編號92521]  

Studying the effects of diosgenin on the neuroimmunological function of menopausal rats: also evaluating the response on the cell level   [NSC 95-2320-B-040-009]   

學術著作 (Publication)

(A) 英文著作 (Referred Paper)

1. Pawlak CR, FS Chen, FY Wu, YJ Ho*. Potential of D-cycloserine in the treatment of behavioral and neuroinflammatory disorders in Parkinson’s disease and studies that need to be performed before clinical trials. Kaohsiung J Med Sci 28(8):  (2012, in press). (SCI).

2. Ho YJ*, FL Chen, SM Liu, AL Wang, YC Li, TJ Lai, SS Huang. Effects of chronic resistive airway loading on behavioral changes in rats. Chin J Physiol (2012, in press) (SCI).

3. Ho YJ*, SY Tai, CR Pawlak, AL Wang, CW Cheng, MH Hsieh. Behavioral and IL-2 Responses to Diosgenin in Ovariectomized Rats. Chin J Physiol (2012, in press) (SCI).

4. Pawlak CR, BD Karrenbauer, P Schneider, YJ Ho. The elevated plus-maze test: differential psychopharmacology of anxiety-elated behavior. Emotion Review 4(1):98-115, Jan. 24, 2012

5. Hsieh MH, SL Gu, SC Ho, CR Pawlak, CL Lin, YJ Ho*, TJ Lai, FY Wu. Effects of MK-801 on recognition and neurodegeneration in MPTP-induced Parkinson’s rat model. Behav Brain Res 229(1): 41-47, Jan. 10, 2012 (SCI)

6. Schneider P, WF Wolfgang, N Schweinfurth, YJ Ho, A Sartorius, R Spanagel, CR Pawlak. Central metabolite changes and activation of microglia after peripheral interleukin-2 challenge. Brain Behav Immun, 26(2): 277-83, Feb. 1, 2012. DOI: doi:10.1016/j.bbi.2011.09.011. (SCI)

7. Chang CC, TC Kuan, YY Hsieh, YJ Ho, YL Sun, CS Lin. Effects of diosgenin on myometrial matrix metalloproteinase-2 and -9 activity and expression in ovariectomized rats. Int J Biol Sci 7: 837-847, July. 7. 2011. (SCI)

8. Hsial CH, CH Wang, YW Kuo, YJ Ho, HL Chen. Fructo-oligosaccharide systemically diminished D-galactose-induced oxidative molecule damages in BALB/cJ mice. Br J Nutr pp 1-6, 20 Sep., 2011. Published online: DOI: 10.1017/S0007114511005150 (SCI)  

9. Schneider P, YJ Ho, R Spanagel, CR Pawlak. A novel elevated plus-maze procedure to avoid the one-trial tolerance problem. Frontiers in Behavioral Neuroscience 5(43):1-8, July 27, 2011. PDF.  

10. Ho YJ* , SC Ho, CR Pawlak, KY Yeh. Effects of D-cycloserine on MPTP-induced behavioral and neurological changes: potential for treatment of Parkinson's disease dementia. Behav Brain Res 219(2): 280-90, 2011. (SCI)  PDF 

11. Huang GJ, SC Ho, CK Lai, SL Gu, MH Hsieh, YJ Ho*. D-cycloserine reverses recognition deficits in MPTP-induced Parkinson’s disease mice model. Proceedings of XVII International Congress of Neuropathology, pp 31-35, 2010.  PDF   

12. Ho SC, GJ Huang, CK Lai, SL Gu, MH Hsieh, Ho YJ*. MPTP-induced animal model of Parkinson’s disease dementia: there are species differences. Proceedings of XVII International Congress of Neuropathology pp 23-29, 2010.  PDF  

13. Sy HN, SL Wu, WF Wang, CH Chen, YT Huang, YM Liou, CS Chiou, CR Pawlak, YJ Ho*. MPTP-induced dopaminergic degeneration and deficits in object recognition in rats are accompanied by neuroinflammation in the hippocampus. Pharmacol Biochem Behav 95: 158-65, 2010. (SCI). PDF

14. Wang AL, YM Liou, CR Pawlak, YJ Ho*. Involvement of NMDA receptors in both MPTP-induced neuroinflammation and deficits in episodic-like memory in Wistar rats. Beha Brain Res 208: 38-46, 2010 (SCI), PDF

15. Wang WF, SL Wu, YM Liou, AL Wang, CR Pawlak, YJ Ho*. MPTP lesion causes neuroinflammation and deficits in object recognition in Wistar rats. Behav Neurosci 123(6): 1261-70, 2009. (SCI), PDF

16. Karrenbauer BD, YJ Ho, V Ludwig, J Löhn, R Spanagel, RKW Schwarting, CR Pawlak. Time-dependent effects of striatal interleukin-2 on open field behaviour in rats. J Neuroimmunol. 208: 10-18, 2009. (SCI), PDF

17. Bauhofer A, YJ Ho, A Schmitt, M Köster, RKW Schwarting, CR Pawlak. Individual behavioral differences in recovery from abdominal sepsis in rats. Inflammation Res 58:1-9, 2009. (SCI), PDF

18. Lee SD, WW Kuo, YJ Ho, AC Lin, CH Tsai, HF Wang, CH Kuo, AL Yang, CY Huang, JM Hwang. Cardiac Fas receptor-dependent and mitochondrial dependent apoptosis in ovariectomized rats. Maturitas 61:268-77, 2008. (SCI), PDF

19. Chiang CY, KY Yeh, SF Lin, H Hsuchou, MY Tai, YJ Ho *, YF Tsai *. Effects of alcohol on the mouse-killing behavior of olfactory bulbectomized rats. Chinese J Physiol 51(6): 408-13, 2008. (SCI), PDF

20. Chen JH, JSS Wu, HC Lin, SL Wu , WF Wang, SK Huang, YJ Ho*. Dioscorea improves the morphometric and mechanical properties of bone in ovariectomized rats. J Sci Food Agr 88: 2700-06, Oct. 7. 2008. (SCI), PDF

21. Pawlak CR*, YJ Ho*, R. K.W. Schwarting*. Animal models of human psychopathology based on individual differences in novelty-seeking and anxiety. Neurosci Biobehav Rev 32: 1544-68, 2008. (SCI), PDF

22. Lee YT, WF Wang, CW Cheng, SL Wu, CR Pawlak, YJ Ho*. Effects of escapable and inescapable stressors on behavior and interleukin-2 in the brain. Neuroreport 19(12): 1243-47, Aug. 6. 2008. (SCI), PDF 

23. Hsieh YS, SF Yang, SC Chu, YJ Ho, CS Kuo, DY Kuo. Transcriptional interruption of cAMP response element binding protein modulates superoxide dismutase and neuropeptide Y-mediated feeding behavior in freely moving rats. J Neurochem 105: 1438-1449, May, 2008. (SCI), PDF 

24. Wu SL, LS Hsu, WT Tu, WF Wang, YT Huang, CR Pawlak^*, YJ Ho^*. Effects of D-cycloserine on the behavior and ERK activity in the amygdala: Role of individual anxiety levels. Behav Brain Res 187(2): 246-53, Mar.5. 2008.  (SCI), PDF

25. Ho YJ*, WY Hsu, CF Wang, T Tseng, CW Cheng, YC Hung, CC Hsu, MD Kao, YF Tsai. Psychoimmunological Effects of Dioscorea in the Ovariectomized Rats: Role of Anxiety Level. Annals of General Psychiatry 6:21, Aug 10, 2007.  【獲頒亞理斯多德研究獎Aristotle Research Award】, PDF

26. Wang WF, T Tseng, WY Hsu, CF Wang, CC Hsu, YJ Ho^*. Effects of Apomorphine on the Expression of Learned Helplessness Behavior. Chinese J Physiol 50(2): 63-68, April 30, 2007. (SCI), PDF

27. Chen LM, WW Kuo, JJ Yang, SG Wang, YL Yeh, FJ Tsai, YJ Ho, MH Chang, CY Huang, SD Lee. Eccentric Cardiac Hypertrophy was Induced by Long-term Intermittent Hypoxia. Exp Physiol 92(2):409-16, 2007. (SCI), PDF

28. Ho YJ*, LS Hsu, CF Wang, WY Hsu, TJ Lai, CC Hsu, YF Tsai. Behavioral effects of D-cycloserine in rats: the role of anxiety level. Brain Res 1043: 179-185, May. 2005. (SCI), PDF

29. Ho YJ, KH Chen, MY Tai, YF Tsai. MK-801 Suppresses Muricidal Behavior But Not Locomotion in Olfactory Bulbectomized Rats: Involvement of NMDA Receptors. Pharmacol Biochem Behav 77:641-646, 2004. (SCI), PDF

30. Ho YJ, H Hsuchou, HA Shui, MY Tai, KH Chen, YF Tsai: Effects of Desipramine and MK-801 on components of muricidal behavior in olfactory bulbectomized rats: an application of incisor-cutting animal model. Neurosci Res Comm 34(3): 136-43, 2004.  (SCI), PDF

31. Ho YJ, CR Pawlak, LH Ku, Schwarting RKW: Acute and long-term consequences of single MDMA administration in relation to individual anxiety levels in the rat. Behav Brain Res 149:135-144, 2004. (SCI), PDF

32. Pawlak CR, YJ Ho, RKW Schwarting, A Bauhofer: Relationship between striatal interleukin-2 mRNA levels and anxiety in the rat. Neurosci Lett 341:205-208, 2003. (SCI), PDF

33. Ho YJ, J Eichendorff, RKW Schwarting: Individual response profiles of male Wistar rats in animal models of anxiety and depression. Behav Brain Res 136:1-12, 2002. (SCI), PDF

34. Hsuchou H, YJ Ho, HA Shui, MY Tai, KH Chen, YF Tsai: Effects of incisor cutting on olfactory bulbectomy-induced muricidal behavior in rats. Physiol and Behav 76 (4-5): 669-75, 2002. (SCI), PDF

35. Ho YJ, TM Liu, MY Tai, CS Wong, YF Tsai: Effects of olfactory bulbectomy on the density of NMDA receptors in rat’s brain: [3H] MK-801 binding assay. Brain Res 900:214-218, 2001. (SCI), PDF

36. Ho YJ, YC Chang, TM Liu, MY Tai, CS Wong, YF Tsai: Striatal glutamate release during novelty exposure-induced hyperactivity in olfactory bulbectomized rats. Neurosci Lett 287 (2):117-120, 2000. (SCI), PDF 

(B) 中文著作 （in Chinese with English abstract）

1. 陳福士、黃國洲、吳富英、何應瑞*。Amantadine抑制巴金森氏症失智及NMDA受體於其中所扮演之角色：文獻回顧與探討。臨床醫學 68(5): 386-92, Nov. 1, 2011 Chen FS, Huang GJ, FY Wu, YJ Ho*. Amantadine suppresses dementia in Parkinson’s disease: role of NMDA receptors: article review. Clinical Medicine 68(5): 386-92, Nov. 1, 2011.  PDF   

2. 莊婷、謝明鴻、陳福士、吳富英、何應瑞*。D-cycloserine加強暴露療法治療恐懼症之效果：文獻回顧。台灣醫學  15(6): 1-11, Jun 21, 2011.。 Chuang T, MH Hsieh, FS Chen, FY Wu, YJ Ho*. D-cycloserine facilitates the effects of exposure therapy on phobias. Formosan J Medicine  15(6): 1-11, Jun 21, 2011 (in Chinese with English abstract).

3. 何應瑞*、巫錫霖、王文甫、施曉雅、黃耀庭。巴金森氏症患者的幻覺及其可能的神經心理機轉。台灣醫學 14(1): 88-96, Jan. 1^st, 2010。 Ho YJ*, SL Wu*, WFu Wang, HS Sy, YT Huang. Hallucinations in Parkinson’s disease: the possible neuropsychological mechanisms, Formosan J Medicine 2009 (in press).（本論文承黃國洲先生繪製插圖，特別致上謝意）PDF

4. 何應瑞*、巫錫霖、王文甫、黃耀庭、鄭鈞文。麩胺酸神經系統與神經免疫功能在巴金森氏症失智的可能角色。台灣醫學 13(1): 100-06, Jan. 1st. 2009。【YJ Ho*, SL Wu, WF Wang, YT Huang, CW Cheng. Role of glutamatergic and neuroimmunological function in the dementia in Parkinson’s disease. Formosan J Medicine 13(1): 100-06, Jan. 1st. 2009】PDF

5. 王慶福、游顯妹、王郁茗、何應瑞、曾淑梅。配合生理回饋之放鬆訓練對重症加護病房護理人員焦慮反應之影響效果（The effects of biofeedback-assisted relaxation on nursing staffs with anxiety reaction in ICU, Chung Shan Medical Journal）。中山醫學雜誌，18(2): 241-53, Dec. 2007。

6. 王慶福、鍾麗珍、王郁茗、何應瑞、賴德仁。生理回饋訓練與放鬆訓練對大學生焦慮與憂鬱反應之影響效果（Effect of biofeedback training and relaxation training on anxiety and depressive reactions of college students, Chung Shan Medical Journal）。中山醫學雜誌，18(2): 255-70, Dec. 2007。

7. 黃秋谷、何應瑞*。搖頭丸，危險的急性中毒與棘手的慢性中毒。臨床藥學雜誌 10(2): 49-62, 2002. (Huang CK, YJ Ho*. “Ecstasy” 3,4 Methylenedioxymethamphetamine: dangerous acute-effects and long-term toxicity. Clinical Pharmacology 10(2): 49-62, 2002.)

8. 何應瑞*、蔡元奮。麩胺酸神經系統在憂鬱症中可能的角色：以嗅球被切除之大鼠為動物模式所得的證據。台灣精神醫學雜誌  19(1): 5-18, 2005. (Ho YJ*, YF Tsai. Possible Role of Glutamatergic System in Depression: Evidence from Animal Model of Olfactory Bulbectomized Rats. Taiwanese J Psych 19(1): 5-18, 2005.)

9.  黃秋谷，王慶福，徐文鈺，賴德仁，何應瑞*。麩胺酸神經系統NMDA受體在精神分裂症之角色：作用在甘胺酸結合位之藥物所得的證據。臨床醫學月刊  55(4): 253-258,   (Huang CK, CF Wang, WY Hsu, TJ Lai, YJ Ho*. Role of glutamatergic NMDA receptor in schizophrenia: evidence from drugs acting at the glycine binding site. Clinical Medicine 55(4): 253-258, Apr. 2005.)  

10. 杜瑋庭、曾鼎、王安莉、鍾宛玲、林俊成、許立松、徐文鈺、王慶福、何應瑞*。NMDA受體在D-cycloserine對焦慮行為作用之角色。台灣醫學 9(2): 173-179, Mar. 2005.      (Tu WT, T Tseng, AL Wang, WL Chung, CC Lin, LS Hsu, WY Hsu, CF Wang, YJ Ho. Effects of D-cycloserine on anxiety behavior: role of NMDA receptor. Formosan Journal of Medicine 9(2): 173-197, 2005. (in Chinese with English abstract))

11. 黃秋谷、王慶福、徐文鈺、黃耀庭、賴德仁、何應瑞*。影響神經功能並參與情感疾病之發炎物質：心理神經免疫學之基礎。臨床醫學月刊 58(1):51-56, 2006。(Huang CK, CF Wang, WY Hsu, YT Huang, TJ Lai, YJ Ho*. Inflammatory substances affecting neuronal function and affective disorders: fundamentals of psychoneuroimmunology. Clinical Medicine 58(1):51-56, 2006. [NSC 93-2320-B-040-015; CSMU 93-OM-B-001; CSMU 93-OM-A-011] (in Chinese with English abstract)

12. 何應瑞。山藥，植物性的賀爾蒙。常春月刊  164:90-93, 1996。 (Ho YJ. Dioscorea, Phytohormone. Evergreen 164:90-93, 1996. (in Chinese with English abstract)

(C) 投稿中 （Submitted）

1. Hsieh MH, SC Ho, KY Yeh⁴, CR Pawlak, HM Chang, YJ Ho*, TJ Lai*, FY Wu. Role of metabotropic glutamate receptors in cognition and neurodegeneration in an MPTP-induced Parkinson’s disease rat model. (Psychopharmacology. 111201) [NSC 100-2410-H-040-003 and NSC 100-2923-H-040-009-MY3]

(D) 會議摘要(超過100篇) (more than 100 conference abstracts)   　 

1.           Yeh KY*, Ho YJ*. Role of metabotropic glutamate receptors in cognitive function and neurodegeneration in MPTP-induced Parkinson’s rat model. The 7^th Congress of the Federations of Asian and Oceanian Physiological Societies (FAOPS), Sep. 11-14, 2011, Taipei, Taiwan, ROC.  

2.            Gu SL, CK Lai, GJ Huang, SC Ho, CY Chou, YC Hung, CW Lin, YJ Ho*. MK-801 reverses recognition deficits and neurodegeneration in MPTP-induced Parkinson’s disease rat mode. The 7^th Congress of the Federations of Asian and Oceanian Physiological Societies (FAOPS), Sep. 11-14, 2011, Taipei, Taiwan, ROC.

3.            Lin CW, SL Gu, CK Lai, GJ Huang, CY Chou, YC Hung, WN Huang, CT Chang, HC Lin, JH Chen, YJ Ho*. Effects of chronic treatment with d-galactose and diosgenin on the bone of male Wistar rats. The 7^th Congress of the Federations of Asian and Oceanian Physiological Societies (FAOPS), Sep. 11-14, 2011, Taipei, Taiwan, ROC. 

4.            Hung YC, SL Gu, CY Chou, GJ Huang, WN Huang, CK Lai, YJ Ho*. Effects of chronic treatment with D-galactose on the behavior in the wistar rats. The 7^th Congress of the Federations of Asian and Oceanian Physiological Societies (FAOPS), Sep. 11-14, 2011, Taipei, Taiwan, ROC. 

5.            Lai CK, SL Gu¹, GJ Huang, SC Ho, CY Chou, YC Hung, CH Chen, AL Wang, KY Yeh, YJ Ho*. Role of NMDA receptors in mptp-induced behavior deficits in animal model of Parkinson’s disease. The 7^th Congress of the Federations of Asian and Oceanian Physiological Societies (FAOPS), Sep. 11-14, 2011, Taipei, Taiwan, ROC.

6.            Ho YJ*. D-cycloserine suppresses MPTP-induced deficits of behavioral and neurological functions. The 12^th European Congress of Psychology. Jul. 04-08, 2011. Istanbul, Turkey.  

7.            Huang WN, MC Ho, YJ Ho*. A 5-arm Maze Study investigating Visuo-spatial Attention in MPTP-induced Animal Model of Parkinson’s Disease. The 12^th European Congress of Psychology. Jul. 04-08, 2011. Istanbul, Turkey.

8.          Tseng LH, YJ Ho, PC Hsu. Exposure to decabrominated diphenyl ether through breast-milk nursing causes hyper-exploratory behavior in mice. The 10^th World Congress of Biological Psychiatry, May 29 – June 2, 2011, Prague, Czech Republic.

9.          Gu SL, CK Lai, GJ Huang, SC Ho, CY Chou, YC Hung, YJ Ho*. Effects of MK-801 on MPTP-induced behavioral deficits in Wistar rats. 第26屆生物醫學年會，Mar. 19-20 2011，台北 

10.      Lai CK, SL Gu, GJ Huang, SC Ho, CY Chou, YC Hung, CH Chen, AL Wang, KY Yeh, YJ Ho*. NMDA receptors are involved in behavioral deficits in animal model of Parkinson’s disease 第26屆生物醫學年會，Mar. 19-20 2011，台北

11.      Ho SC, AL Wang, CH Chen, YJ Ho*. Effects of D-cycloserine on MPTP-induced behavioral and neurological changes: the potential in the treatment of Parkinson’s disease dementia. Taiwanese Psychology Association 49^th Conference, Nov. 6-7, 2010, Chia-Yi, Taiwan.

12.        Lai CK. SL Gu, GJ Huang, SC Ho, CY Chou, YC Hung, KY Yeh*, YJ Ho*. MK-801抑制MPTP所誘發之巴金森氏症動物的認知行為障礙. Taiwanese Psychology Association 49^th Conference, Nov. 6-7, 2010, Chia-Yi, Taiwan.

13.         Huang GJ, CK Lai, SL Gu, SC Ho, MH Hsieh*, YJ Ho*. D-cycloserine reverses recognition deficits in MPTP-induced Parkinson’s disease mice model. Taiwanese Psychology Association 49^th Conference, Nov. 6-7, 2010, Chia-Yi, Taiwan.

14.         Ho YJ*, SC Ho, GJ Huang, CK Lai, SLin Gu. D-cycloserine and amantadine reverse recognition deficits in MPTP-induced Parkinson’s disease mice model. XVIIth International Congress of Neuropathology, September 11-15, 2010, Salzburg, Austria. 

15.         Ho SC, AL Wang, CH Chen, YJ Ho*. Effects of D-cycloserine on the behavioral changes and neurodegeneration in MPTP-induced Parkinson’s disease animal model. XVIIth International Congress of Neuropathology, September 11-15, 2010, Salzburg, Austria. 

16.         張千代、陳建宏、何應瑞、紀偉民、陳曉鈴。薯蕷皂甘元(Diosgenin)對於去卵巢大鼠行為之效益。台灣營養學會第三十六屆年會。May. 21-22, 2010，台北新莊。

17.         郭怡文、陳曉鈴、林玉鳳、徐瑋婷、何應瑞。以D-半乳糖誘發老化小鼠為模式探討果寡醣對氧化壓力的調節與保護腸道細胞對抗氧化傷害之作用。台灣營養學會第三十六屆年會。May. 21-22, 2010，台北新莊。

18.         Chang SH, LH Tseng, YJ Ho, PC Hsu. Spontaneous behavior and learning and memory of the adult mice offspring after gestational and lactation exposure to the decabrominated diphenyl ether. (oral) 5^th International Symposium Brominated Flame Retardants. Kyoto, Japan. Apr. 7-9, 2010.

19.         Ho YJ*, AL Wang, SC Ho, KJ Huang, YM Liou. Effects of D-cycloserine on MPTP-induced neuroinflammation and behavioral deficits in Wistar rats. (oral). The 25^th Joint Annual Conference of Biomedical Science, 27-28, Mar. Taipei, ROC, 2010.

20.         Wang AL, FL Chen, SM Liu, YC Li, SS Huang, YJ Ho*. Effects of chronic airway obstruction on learning in rats. (oral). The 25^th Joint Annual Conference of Biomedical Science, 27-28, Mar. Taipei, ROC, 2010.

21.         Gu SL, CK Lai, GJ Huang, CW Wang, SC Ho, YJ Ho*. D-cycloserine和amantadine對MPTP處理之C57BL/6小鼠的認知、情緒、學習之影響. The 25^th Joint Annual Conference of Biomedical Science, 27-28, Mar. Taipei, ROC, 2010.

22.         Ho SC, GJ Huang, SL Gu, CW Wang, CK Lai, YJ Ho*. MPTP-induced animal model of Parkinson’s disease dementia: there are species differences. (oral). The 25^th Joint Annual Conference of Biomedical Science, 27-28, Mar. Taipei, ROC, 2010. 

23.         Liu JY, PC Hsu, LH Tseng, YJ Ho. A dose–response study following in utero and lactational exposure to decabrominated diphenyl ether (PBDE 209): effects on early neurobehavior in mice offspring. The 25^th Joint Annual Conference of Biomedical Science, 27-28, Mar. Taipei, ROC, 2010.

24.         Ho SC, KJ Huang, YJ Ho*. Role of NMDA receptors on animal model of Parkinson’s disease dementia. Brain circuits – from receptors to network dynamics, Research workshop of the Israel science foundation. Ein-gedi, Israel, Jan. 31 – Feb. 4, 2010.

25.         Huang GJ, SC Ho, SL Gu, CW Wang, CK Lai, YJ Ho*. Role of NMDA receptors on mice model of Parkinson’s disease: effects of D-cycloserine and amantadine. Brain circuits – from receptors to network dynamics, Research workshop of the Israel science foundation. Ein-gedi, Israel, Jan. 31 – Feb. 4, 2010.

26.         Wu FY, GJ Huang, WN Huang, YJ Ho*. Visuo-spatial Attention in MPTP-induced Animal Model of Parkinson’s Disease: Testing in The 5-arm maze. Brain circuits – from receptors to network dynamics, Research workshop of the Israel science foundation. Ein-gedi, Israel, Jan. 31 – Feb. 4, 2010.

(E) 專利申請 Innovation Patenting

1.      Ho YJ*, PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF NEURODEGENERATIVE DISORDERS 「用於治療神經退化性疾病之醫藥組合物」。D-cycloserine治療PDD。申請美國。申請號：12/940,401, 申請日：2010.11.05。

2.      Ho YJ*, Chung Shan Medical University. 用於治療神經退化性疾病之醫藥組合物 (Pharmaceutical compositions for treatment of neurodegenerative disorders). 2009. 申請案號Application no.: 098145509. 台灣ROC。

3. Ho YJ*, Chung Shan Medical University.使用薯蕷皂素來改善與停經期症候群有關聯的認知缺陷IMPROVEMENT OF COGNITIVE DEFICIT ASSOCIATED WITH MENOPAUSal syndrome WITH DIOSGENIN。申請案號99139715台灣  

4. Ho YJ*，陳建宏 diosgenin。使用薯蕷皂素來改善停經症候群有關聯的認知缺陷（主張TW優先）。美國。國外編號：PE41589。

5.  Ho YJ*，陳建宏 diosgenin。使用薯蕷皂素來改善停經症候群有關聯的認知缺陷（主張TW優先）。中國。國外編號：PE41968。

(F) 學位論文 (Thesis)

  1.  Ho YJ: Glutamatergic system in the amygdala and striatum is involved in the mouse-killing behavior and novelty exposure-induced hyperactivity in olfactory bulbectomized rats. 2002.

  2. Ho YJ: Effects of excitatory amino acid and antipsychotics, haloperidal and amperozide, on dopamine transmission in rat’s nucleus accumbens and striatum. 1994.  

(G) 專書 (Books)

1. 王春美、何應瑞、施柯念、秦作威、高婷玉、溫小娟、葉睿毅、廖美華、滿庭芳、駱明潔、盧敏吉、顏惠芷。新編生理學。華格那企業有限公司，2004年，台中市。

2. 吳莉玲、朱冠州、何應瑞。生理學精要。藝軒圖書出版社，2003年，台北市。(ISBN 9576167108)

3. 吳莉玲、何應瑞。生理學精華。藝軒圖書出版社，2002年，台北市。(ISBN 9576166799)

(H) 其他 (Others)

1. 何應瑞: 精神分裂症多巴胺假說的演進

2. 何應瑞: 生理心理學介紹

山藥與更年期相關研究著作 (Dioscorea & menopause topics)

1. Ho YJ*, SY Tai, CR Pawlak, AL Wang, CW Cheng, MH Hsieh. Behavioral and IL-2 Responses to Diosgenin in Ovariectomized Rats. Chinese Journal of Physiology (Apr. 12, 2011, in press) (SCI).  （薯蕷皂苷影響停經動物之行為及腦內IL-2含量）

3. Lee SD, WW Kuo, YJ Ho, AC Lin, CH Tsai, HF Wang, CH Kuo, AL Yang, CY Huang, JM Hwang. Cardiac Fas receptor-dependent and mitochondrial dependent apoptosis in ovariectomized rats. Maturitas 61:268-77, 2008. (SCI), PDF （停經後加速心肌細胞凋亡及心臟腫大可能因此導致心臟衰竭）

4.Chen JH, JSS Wu, HC Lin, SL Wu , WF Wang, SK Huang, YJ Ho*. Dioscorea improves the morphometric and mechanical properties of bone in ovariectomized rats. J Sci Food Agr 88: 2700-06, Oct. 7. 2008. (SCI), PDF （山藥改善停經後之骨質疏鬆，增加骨骼強度）

5.Ho YJ*, WY Hsu, CF Wang, T Tseng, CW Cheng, YC Hung, CC Hsu, MD Kao, YF Tsai. Psychoimmunological Effects of Dioscorea in the Ovariectomized Rats: Role of Anxiety Level. Annals of General Psychiatry 6:21, Aug 10, 2007.  【獲頒歐洲亞理斯多德研究獎Aristotle Research Award】, PDF （山藥降低停經後之焦慮與憂鬱，改善中樞神經免疫功能）

6.何應瑞*。山藥，植物性的賀爾蒙。常春月刊  164:90-93, 1996。 (Ho YJ. Dioscorea, Phytohormone. Evergreen 164:90-93, 1996.