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研究特色

研究主題: 探討精神疾病（特別是焦慮、憂鬱症）與精神藥物的神經機轉，也包括毒品的神經毒性。研究中以微透析技術（microdialysis）、放射線受體標定技術（receptor binding）、腦部冷凍切片（brain slice）、高壓液相層析（HPLC）及Western blot、ELISA蛋白質測定法測量神經化學物質及神經功能之變化。[精神分裂症--多巴胺假說之演進]

神經行為實驗室：運用高腳十字迷宮（elevated plus-maze）、開放空間行為測定儀（open field）、往復式觀察箱（shuttle box）、forced swim test等儀器輔助測定動物之行為表現，例如運動、學習、記憶、焦慮、憂鬱及攻擊等行為，並結合生化及分子生物學的技術，從分子層面深入探討神經、免疫與心理功能。 [生理心理學--介紹]

研究目標：進一步精神疾病的神經機轉，以期開發更有效的醫療方法。近年之研究成果已陸續發表於Physiology and Behavior、Brain Research、 Pharmacology Biochemistry and Behavior、 Neuroscience Letters及 Behavioral Brain Research 等學術期刊。

研究現況與未來發展

   執行之研究計畫主題包括: 「D-cycloserine 對憂鬱症動物模式其壓力行為之影響：NMDA受體的可能角色」、「基側杏仁核調節壓力環境中行為及神經活性之角色：以嗅球切除之大鼠為憂鬱症模式」、「山藥對停經動物焦慮及憂鬱行為之影響: 神經免疫功能之角色」、「山藥對切除卵巢之雌鼠的骨密度及機械特性之功效」等。規劃中之研究主題將更深入探討淮山等中藥成分對麩胺酸（glutamate）神經系統、精神疾病及神經毒性之角色，藥物濫用者神經系統功能之變化也是有興趣的主題。歡迎有興趣的同學及學者一起合作，共同進行精神疾病及神經行為領域之研究。

專題研究計畫  

不可逃避之壓力對神經免疫功能的影響：多巴胺神經系統與腦內細胞激素在憂鬱症動物模式之角色

Studying the effects of diosgenin on the neuroimmunological function of menopausal rats: also evaluating the response on the cell level

探討薯蕷皂甘對停經大鼠之神經免疫功能的影響：一併探討細胞層面之效果

(NSC 95-2320-B-040-009)

The role of anxiety level in the effects of D-cycloserine on the stress response and mitogen-activated protein kinase (NSC 93-2320-B-040-015)

A study on the effects of dietary supplement of dioscorea on the anxiety and depression in ovariectomized rats

探討飲食中補充山藥對卵巢切除之動物焦慮及憂鬱行為的影響 (CSMU 93-OM-B-001)

Role of basolateral amygdala in stress-induced behavioral and neuronal responses: depression animal model of olfactory bulbectomized rats

(NSC 92-2320-B-040-022)

Effects of D-cycloserine on the stress response and mitogen-activated protein kinase: role of anxiety level (CSMU 92-OM-B-006)

Effects of D-cycloserine on the stress response in depression animal model: role of NMDA receptors (CSMU 91-OM-B-021)

學術著作 (Publication)

(A) 英文著作 (Referred Paper)

1. Bauhofer A, YJ Ho, A Schmitt, M Köster, RKW Schwarting, CR Pawlak. Individual behavioral differences in recovery from abdominal sepsis in rats. Inflammation Res (2008, in press) (SCI)

2. Lee SD, WW Kuo, YJ Ho, AC Lin, CH Tsai, HF Wang, CH Kuo, AL Yang, CY Huang, JM Hwang. Cardiac Fas receptor-dependent and mitochondrial dependent apoptosis in ovariectomized rats. Maturitas (2008, in press) (SCI)

3. Pawlak CR*, YJ Ho*, R. K.W. Schwarting*. Animal models of human psychopathology based on individual differences in novelty-seeking and anxiety. Neuroscience & Biobehavioral Reviews 32: 1544-68, 2008. (SCI)

4. Lee YT, WF Wang, CW Cheng, SL Wu, CR Pawlak, YJ Ho^*. Effects of escapable and inescapable stressors on behavior and interleukin-2 in the brain. Neuroreport 19(12): 1243-47, Aug. 6. 2008. (SCI)

5.  Chiang CY, KY Yeh, SF Lin, H Hsuchou, MY Tai, YJ Ho ^*, YF Tsai ^*. Effects of alcohol on the mouse-killing behavior of olfactory bulbectomized rats. Chinese J Physiol (2008, in press). (SCI)

6. Hsieh YS, SF Yang, SC Chu, YJ Ho, CS Kuo, DY Kuo. Transcriptional interruption of cAMP response element binding protein modulates superoxide dismutase and neuropeptide Y-mediated feeding behavior in freely moving rats. J Neurochem 105: 1438-1449, May, 2008. (SCI). 

7. Wu SL, LS Hsu, WT Tu, WF Wang, YT Huang, CR Pawlak^*, YJ Ho^*. Effects of D-cycloserine on the behavior and ERK activity in the amygdala: Role of individual anxiety levels. Behav Brain Res 187(2): 246-53, Mar.5. 2008.  (SCI)

8. Ho YJ*, WY Hsu, CF Wang, T Tseng, CW Cheng, YC Hung, CC Hsu, MD Kao, YF Tsai. Psychoimmunological Effects of Dioscorea in the Ovariectomized Rats: Role of Anxiety Level. Annals of General Psychiatry 6:21, Aug 10, 2007. (on-line publication: http://www.annals-general-psychiatry.com/content/6/1/21). 【獲頒亞理斯多德研究獎Aristotle Research Award; 頒發單位：The International Society on Brain and Behaviour：http://www.psychiatry.gr/main_brain2_eng.html】

9. WF Wang, T Tseng, WY Hsu, CF Wang, CC Hsu, YJ Ho^*. Effects of Apomorphine on the Expression of Learned Helplessness Behavior. Chinese J Physiol 50(2): 63-68, April 30, 2007. (SCI).

10. Chen LM, WW Kuo, JJ Yang, SG Wang, YL Yeh, FJ Tsai, YJ Ho, MH Chang, CY Huang, SD Lee. Eccentric Cardiac Hypertrophy was Induced by Long-term Intermittent Hypoxia. Exp Physiol Mar, 92(2):409-16, 2007. (SCI)

11. Cheng CW, T Tseng, WT Tu, YCHung, WY Hsu, CF Wang, MD Kao, YJ Ho*, Psychoimmunological Effects of Dioscorea in the Ovariectomized Rats. Annals of General Psychiatry 4(suppl 1): S112, 2005.

12. Tseng T, YC Chen, WY Hsu, CF Wang, YJ Ho*. Role of the dopamine receptors in the development of learned helplessness. Annals of General Psychiatry 4(suppl 1): S137, 2005.

13. Ho YJ*, LS Hsu, CF Wang, WY Hsu, TJ Lai, CC Hsu, YF Tsai. Behavioral effects of D-cycloserine in rats: the role of anxiety level. Brain Res 1043: 179-185, May. 2005. (SCI)

14. Ho YJ, KH Chen, MY Tai, YF Tsai. MK-801 Suppresses Muricidal Behavior But Not Locomotion in Olfactory Bulbectomized Rats: Involvement of NMDA Receptors. Pharmacol Biochem Behav 77:641-646, 2004. (SCI)

15. Ho YJ, H Hsuchou, HA Shui, MY Tai, KH Chen, YF Tsai: Effects of Desipramine and MK-801 on components of muricidal behavior in olfactory bulbectomized rats: an application of incisor-cutting animal model. Neurosci Res Comm 34(3): 136-43, 2004.  (SCI)

16. Ho YJ, CR Pawlak, LH Ku, Schwarting RKW: Acute and long-term consequences of single MDMA administration in relation to individual anxiety levels in the rat. Behav Brain Res 149:135-144, 2004. (SCI)

17. Pawlak CR, YJ Ho, RKW Schwarting, A Bauhofer: Relationship between striatal interleukin-2 mRNA levels and anxiety in the rat. Neurosci Lett 341:205-208, 2003. (SCI)

18. Ho YJ, J Eichendorff, RKW Schwarting: Individual response profiles of male Wistar rats in animal models of anxiety and depression. Behav Brain Res 136:1-12, 2002. (SCI)

19. Hsuchou H, YJ Ho, HA Shui, MY Tai, KH Chen, YF Tsai: Effects of incisor cutting on olfactory bulbectomy-induced muricidal behavior in rats. Physiol and Behav 76 (4-5): 669-75, 2002. (SCI)

20. Pawlak CR, A Bauhofer, YJ Ho, Schwarting RKW. Relationships between anxiety and basal IL-2 mRNA levels in the striatum of the rat. Immunobiology 206: 318, 2002.

21. Ho YJ, TM Liu, MY Tai, CS Wong, YF Tsai: Effects of olfactory bulbectomy on the density of NMDA receptors in rat’s brain: [3H] MK-801 binding assay. Brain Res 900:214-218, 2001. (SCI)

22. Ho YJ, YC Chang, TM Liu, MY Tai, CS Wong, YF Tsai: Striatal glutamate release during novelty exposure-induced hyperactivity in olfactory bulbectomized rats. Neurosci Lett 287 (2):117-120, 2000. (SCI) 

(B) 中文著作 （in Chinese with English abstract）

1. 何應瑞*、巫錫霖、王文甫、黃耀庭、鄭鈞文。麩胺酸神經系統與神經免疫功能在巴金森氏症失智的可能角色。台灣醫學，2008（出版中）。【Ying-Jui Ho^*, Shey-Lin Wu, Wen-Fu Wang, Yao-Ting Huang, Chun-Wen Cheng. Role of glutamatergic and neuroimmunological function in the dementia in Parkinson’s disease. Formosan J Medicine, 2008 (in press).】

2. 王慶福、游顯妹、王郁茗、何應瑞、曾淑梅。配合生理回饋之放鬆訓練對重症加護病房護理人員焦慮反應之影響效果。中山醫學雜誌，2008（出版中）（The effects of biofeedback-assisted relaxation on nursing staffs with anxiety reaction in ICU, Chung Shan Medical Journal）

3. 王慶福、鍾麗珍、王郁茗、何應瑞、賴德仁。生理回饋訓練與放鬆訓練對大學生焦慮與憂鬱反應之影響效果。中山醫學雜誌，2008（出版中）（Effect of biofeedback training and relaxation training on anxiety and depressive reactions of college students, Chung Shan Medical Journal）

4. 黃秋谷、何應瑞*。搖頭丸，危險的急性中毒與棘手的慢性中毒。臨床藥學雜誌 10(2): 49-62, 2002. (CK Huang, YJ Ho*. “Ecstasy” 3,4 Methylenedioxymethamphetamine: dangerous acute-effects and long-term toxicity. Clinical Pharmacology 10(2): 49-62, 2002.)

5. 何應瑞*、蔡元奮。麩胺酸神經系統在憂鬱症中可能的角色：以嗅球被切除之大鼠為動物模式所得的證據。台灣精神醫學雜誌