Dr. Yen-Chein Lai

Curriculum Vitae

Born in Taiwan (Republic of China) 02/20/1967

Sex: Female                                            

Address: No. 110, Sec. 1, Rd. Chien Kuo N., Taichung 402, Taiwan

Tel: 886-4-24730022 ext 12385 Fax: 886-4-24739030                            

E-mail: yenchein@csmu.edu.tw

Education

Harvard Medical School, Cancer Biology and Therapeutics, 1-year Training Program (2015 - 2016)

PhD in Biochemistry, National Taiwan University College of Medicine, 1996 June

B. Sc. degree in Medical Technology, National Taiwan University College of Medicine, 1989 June

Experience

Post Doctoral Fellow, National Taiwan University College of Medicine, 1996 September to 1997 July

Post Doctoral Fellow, Chang-Gung Memorial Hospital, 1997 August to 1998 January

Adjunct Assistant Professor, Chang-Gung Memorial Hospital, 1997 August to 1998 January

Visit scholar, Joslin Diabetes Center, 2006 July to August

Visit scholar, Joslin Diabetes Center, 2008 July to August

Harvard Medical School, Cancer Biology and Therapeutics, 1-year Training Program (2015 - 2016)

Assistant Professor, Chung Shan Medical University, 1998 February until present

Awards and Honors

2014 AACC International Travel Grant

2010 Royan International Twin Congress Travel Grant

2009 & 2013 Annual Excellent Tutorial Adviser in Chung Shan Medical University 

2002 IFCC International Travel Grant

1996 1ST Dr. Chien-Tien Hsu’s Science Award Given by Chinese Society of Cell and Molecular Biology

Editor services

Editor for SM Journal of Gynecology and Obstetrics, 2015 February until present

Editor for SRL Nephrology & Therapeutics, 2015 December until present

Editor for International Journal of Reproduction, Fertility & Sexual Health (IJRFSH), 2016 January until present

Editor for Source Journal of Ovarian Research, 2016 May until present

Editor for Annals of Pancreatic Disorders and Treatment, 2016 June until present

Editor for International Journal of Research Studies in Medical and Health Sciences (IJRSMHS), 2016 June until present

Editor for Clinical and Diagnostic Pathology, 2016 August until present

Editor for Insights in Obstetrics and Gynaecology, 2016 October until present

Associate Editor for Open Access Journal of Microbiology & Biotechnology, 2016 October until present

Professional Memberships

2001 until present – Member, American Association for Clinical Chemistry

1998 until present -- Member, Taiwan Society of Laboratory Medicine

Publications

1. Wen-Chung Wang, Tai-Cheng Hou, Chen-Yun Kuo, Yen-Chein Lai*. (2020 April) Hints from a Female Patient with Breast Cancer Who Later Presented with Cowden Syndrome. J Breast Cancer 23: 430-437.

2. Meng-Yao Lu, Wen-Chung Wang, Tai-Cheng Hou, Chen-Yun Kuo, Yen-Chein Lai*. (2020 March) Methylation Statuses of H19DMR and KvDMR at WT2 in Wilms Tumors in Taiwan. Pathology & Oncology Research 26: 2153-2159.

3. Ming-Ru Chiang, Chi-Wen Kuo, Wen-Chung Wang, Tai-Cheng Hou, Chen-Yun Kuo, Meng-Yao Lu, Yen-Chein Lai*. (2019 January) Correlations between Histological and Array Comparative Genomic Hybridization Characterizations of Wilms Tumor. Pathology & Oncology Research 25:1199–1206.

4. Wen-Chung Wang, Yen-Chein Lai*. (2017 June) Mature cystic teratomas of the ovary—reply. Human Pathology 64: 233-234.

5. Wen-Chung Wang, Ya-Ting Lee, Yen-Chein Lai*. (2017 March) PMS2 gene mutation results in DNA mismatch repair system failure in a case of adult granulosa cell tumor. Journal of Ovarian Research 10: 22.

6. Wen-Chung Wang, Yen-Chein Lai*. (2017 March) Evidence of metachronous development of ovarian teratomas: a case report of bilateral mature cystic teratomas of the ovaries and systematic literature review. Journal of Ovarian Research 10: 17.

7. Wen-Chung Wang, Yen-Chein Lai*. (2016 June) Genetic analysis results of mature cystic teratomas of the ovary in Taiwan disagree with the previous origin theory of this tumor. Human Pathology 52: 128-135.

8. Wen-Chung Wang, Yen-Chein Lai*. (2015 June) Commentary on “Epab and Pabpc1 are Differentially Expressed in the Postnatal Mouse Ovaries” SM J Obstet Gynecol 1: 1001.

9. Wen-Chung Wang, Mei-Hua Tsou, Hui-Ju Chen, Wei-Fang Hsu, Yen-Chein Lai*. (2014, September) Two single nucleotide polymorphisms in the von Hippel-Lindau tumor suppressor gene in Taiwanese with renal cell carcinoma. BMC Research notes 7: 638.

10. Wen-Chung Wang, Yen-Chein Lai*. (2014 September) Molecular pathogenesis in granulosa cell tumor is not only due to somatic FOXL2 mutation. Journal of Ovarian Research 7: 88.

11. Meng-Yao Lu, Wen-Chung Wang, Chiao-Wen Lin, Alice Chang, Yen-Chein Lai*. (2014, February) Identification of a constitutional mutation in the WT1 gene in Taiwanese patients with Wilms tumor. Advances in Bioscience and Biotechnology 5: 230-234.

12. Wen-Chung Wang, Angela Shin-Yu Lien, Yen-Chein Lai, Yi-Der Jiang. (2013, May) Commentary on the effects of gestational hypertension on new-onset diabetes mellitus. Journal of Diabetes Investigation 4: 245-246.

13. Wen-Chung Wang, Mour-Shyuarn Lee, Jiunn-Liang Ko, and Yen-Chein Lai. (2011 November) Origin of Uterine Teratoma Differs From That of Ovarian Teratoma: A Case of Uterine Mature Cystic Teratoma. Int J Gynecol Pathol 30: 544–548.

14. Wen-Chung Wang, Hui-Ju Chen, Wei-Pang Shu, Yi-Chang Tsai, and Yen-Chein Lai. (2011 November) The Allele Frequency of Two Single Nucleotide Polymorphisms in the von Hippel-Lindau (VHL) Tumor Suppressor Gene in the Taiwanese Population. J Formos Med Assoc 110: 646-651.

15. Ching-Hsiung Lin, Gwo-Tarng Sheu, Yu-Wen Lin, Chin-Shui Yeh, Yu-Hsin Huang, Yen-Chein Lai, Jan-Gowth Chang, Jiunn-Liang Ko, (2010 September) A new immunomodulatory protein from Ganoderma microsporum inhibits epidermal growth factor mediated migration and invasion in A549 lung cancer cells. Process Biochemistry 45: 1537–1542.

16. Wen-Chung Wang, Hui-Ju Chen, Yu-Hua Tseng, Yen-Chein Lai. (2009 November) Identification of somatic mutations in the von Hippel-Lindau (VHL) gene in a Taiwanese patient with renal cell carcinoma. J Formos Med Assoc 108: 886-893.

17.Yen-Chein Lai, Wen-Chung Wang, Jiann-Jou Yang, and Shuan-Yow Li. (2009 July) Expansion of CAG repeats in the spinocerebellar ataxia type 1 (SCA1) gene in idiopathic oligozoospermia patients. J Assist Reprod Genet 26:257–261.

18. Chuan-Bin Lee, Yen-Chein Lai, Yueh-Hsin Ping, Zhi-Shun Huang, Jung-Yaw Lin, and Huey-Nan Wu. (1996 September) The importance of the helix 2 region for the cis-cleaving and trans-cleaving activities of hepatitis delta virus ribozymes. Biochemistry 35: 12303-12312.

19.Yen-Chein Lai, Jing-Yu Lee, Huey-Juan Liu, Jung-Yaw Lin, and Huey-Nan Wu. (1996 January) Effects of circular permutation on the cis-cleaving reaction of a hepatitis delta virus ribozyme: application to trans-acting ribozyme design. Biochemistry 35: 124-131.

20. Jyh-Cheng Hsieh, See-Chang Huang, Woan-Ling Chen, Yen-Chein Lai, Ming F. Tam. (1991 August) Cysteine-86 is not needed for the enzymic activity of glutathione S-transferase 3-3. Biochem J. 278: 293-7.

21. Wen-Chung Wang, Yen-Chein Lai. (2013 March) Molecular tumor markers and their clinical applications. Bulletin of Taiwan society of laboratory medicine. 28(1): 14-25. (Chinese)

22. Wen-Chung Wang, Yen-Chein Lai. (2011 December) Recent knowledge in bacterial targets of molecular-based tests. Bulletin of Taiwan society of laboratory medicine. 26(4): 5-13. (Chinese)

23. Wen-Chung Wang, Yen-Chein Lai. (2011 March) The role of medical laboratory in personal medicine. Bulletin of Taiwan society of laboratory medicine. 26(1): 1-5. (Chinese)

24. Wen-Chung Wang, Yen-Chein Lai. (2010 June) Reliably detects premature rupture of fetal membranes: The Actim PROM test detects IGFBP-1. Bulletin of Taiwan society of laboratory medicine. 25(2): 1-5. (Chinese)

Symposium

1. Ming-Ru Chiang, Chi-Wen Kuo, Wen-Chung Wang, Tai-Cheng Hou, Chen-Yun Kuo, Meng-Yao Lu, and Yen-Chein Lai. (2018, Sep) Correlations between histological and array comparative genomic hybridization characterizations of Wilms tumor. *The 33rd World Congress of Biomedical Laboratory Science (IFBLS) (Poster)

2.Wen-Chung Wang, Yen-Chein Lai. (2016, May) Genetic analysis results of ovarian mature cystic teratomas in Taiwan disagree with the previous origin theory of this tumor. BIT’s 9th Annual World Cancer Congress-2016. (Invited speaker)

3.Yen-Chein Lai. (2015 July) Molecular pathogenesis in granulosa cell tumor is not only due to somatic FOXL2 mutation. Global Summit on Healthcare & Fitness Summit (Health Care-2015). (Oral presentation)

4.Yen-Chein Lai, Meng-You Lu, Wen-Chung Wang, Chiao-Wen Lin, and Alice Chang. (2014, May) Identification of a constitutional mutation in the WT1 gene in Taiwanese patients with Wilms tumor. BIT’s 7th Annual World Cancer Congress-2014. (Invited speaker)

5.Yen-Chein Lai. (2013, May) Two single nucleotide polymorphisms in the von Hippel-Lindau (VHL) tumor syppressor gene in Taiwanese with or without renal cell carcinoma. BIT’s 6th Annual World Cancer Congress-2013. (Invited speaker)

6.Wen-Chung Wang, Hui-Ju Chen, Wei-Fang Shu, and Yen-Chein Lai. (2012 July) Are the single nucleotide polymorphisms in the von Hippel-Lindau (VHL) tumor suppressor gene associated with renal cell carcinoma (RCC) occurrence? 2012 AACC Annual Meeting & Clinical Lab Expo.

7.Wen-Chung Wang, Mour-Shyuarn Lee, Jiunn-Liang Ko, and Yen-Chein Lai. (2010 November) Origin of uterine teratoma differs from that of ovarian teratoma: a case of uterine teratoma. BIT’s Annual Tetra-Congress of MolMed-2010 Theme: from Molecular Structure to Functions. (Invited speaker)

8.Wen-Chung Wang, Hui-Ju Chen, Wei-Pang Shu, Yi-Chang Tsai, and Yen-Chein Lai. (2010 October) The Allele Frequency of Two Single Nucleotide Polymorphisms in the von Hippel-Lindau (VHL) Tumor Suppressor Gene in the Taiwanese Population. 2010 Annual Meeting of Taiwan society of laboratory medicine.

9.Wen-Chung Wang, Mour-Shyuarn Lee1, Jiunn-Liang Ko, and Yen-Chein Lai. (2010 October) The application of short tandem repeat (STR) analysis on pathogenesis: use uterine teratoma as an example. 2010 Annual Meeting of Taiwan society of laboratory medicine.

10.Mour-Shyuarn Lee, Wen-Chung Wang, and Yen-Chein Lai. (2010 March) Teratoma. 2010 Annual Meeting of Taiwan association of obstetrics and gynecology.

11.Yen-Chein Lai, Wen-Chung Wang, Jiann-Jou Yang, and Shuan-Yow Li. (2010 September) Expansion of CAG repeats in the spinocerebellar ataxia type 1 (SCA1) gene in idiopathic oligozoospermia patients. Royan International Twin Congress 2010 11th Congress on Reproductive Biomedicine & 6th Congress on Stem Cell Biology and Technology. (Oral presentation)

12.TJ Schulz, TL Huang, YC Lai, M Cerletti, JL Shadrach, S Hettmer, AJ Wagers, YH Tseng (2009 June) Identification of Brown Fat Progenitors in Skeletal Muscle: Impact of Bone Morphogenetic Protein 7. The Endocrine Society’s Annual Meeting (ENDO 09)

13.Hongbin Zhang, Tim J. Schulz, Daniel O. Espinoza, Tian Lianhuang, Jianmei Li, Yen-Chein Lai, Steven J. Russell, Brice Emanuelli, Karsten Kristiansen, Yu-Hua Tseng (2009 June) Crosstalk between Insulin and BMP Signaling Systems in Brown Adipogenesis. 69th Scientific Seccions of DiabetesPro.

14.Yen-Chein Lai, Wen-Chung Wang, Hui-Ju Chen (2006 March) Somatic mutations in the von Hippel-Lindau gene in a Taiwanese with renal cell carcinoma. San Diego Conference: DNA Probe Technology—Two Decades of Innovation.

15.Yen-Chein Lai, Wen-Chung Wang, Hui-Ju Chen, and Wei-Fran Hsu (2004 July) The –128 A/G polymorphism in the promoter region of von Hippel-Lindau (VHL) tumor suppressor gene and its potential association with sporadic renal cell carcinoma (RCC).  2004 AACC Annual Meeting and Clinical Lab Expo

16.Wen-Chung Wang, Yen-Chein Lai, Shuan-Yow Li. (2004 July) Trinucleotide repeats numbers are correlated with human oligospermia. 2004 AACC Annual Meeting and Clinical Lab Expo

17.Yen-Chein Lai, Hui-Ju Chen, Wen-Chung Wang. (2003 March) The allele frequency of 1149 A/G poltmorphism in the 3’ untranslated region of the von Hippel-Lindau (VHL) tumor suppressor gene from Taiwanese. The 18th Annual San Diego Conference—Cool Tools III: New Technologies for Molecular Diagnostics.

18.Yen-Chein Lai, Hui-Ju Chen, Wen-Chung Wang. (2002 October) The –128 A/G polymorphism in the promoter region of von Hippel-Lindau (VHL) tumor suppressor gene from Taiwanese. Clinical Chemistry and Laboratory Medicine 40: s131.

19.Wen-Chung Wang, Yen-Chein Lai, Shuan-Yow Li. (2002 October) Has nuclear encoding mitochondrial DNA polymerase impact male infertility? Clinical Chemistry and Laboratory Medicine 40: s131.

20.Yen-Chein Lai, Jing-Yu Lee, Zhi-Shun Huang, Jung-Yaw Lin, and Huey-Nan Wu (1996) Effects of circular permutation on the cis-cleaving reaction of a hepatitis delta virus ribozyme: application to trans-acting ribozyme design. The first annual meeting of the RNA society. Pp. 284.