F(Jaw-Ji Yang), Ph.D.

Professor

B.S.         Dept. of Biology

Tunghai University

M.S.      Institute of Genetics

National Yang-Ming Medical College

Ph.D.      Dept. of Biochemistry

Mount Sinai School of Medicine of The City University of New York

e-mail: jjyang@ csmu.edu.tw

Experiences:

Assistant Professor  School of Dentistry,  Chung Shan Medical College  Oct, 1997-Jan, 2001

Assistant Professor  Institute of Molecular Biology,  National Chung Cheng University   Feb, 2001-Aug, 2001

Associate Professor  School of Dentistry,  Chung Shan Medical University  Aug, 2001-Jan, 2005

Signal Transduction, Cell Growth, Cell Differentiation and Apoptosis

Research in my lab seeks to understand how signal transduction pathways regulate cell proliferation and differentiation, and how such pathways go awry during oncogenesis. . One major focus of our work centers on a novel protein kinase, the mixed lineage kinase, designated ZAK as shown in the figure. Moreover, ZAK may specifically activate JNK and turn on NF-kB transcription factor in several cell lines. The over expression of this gene induces apoptosis in hepatoma cells.

Publications:

Tsai, C. W., Chen, H, W., Yang, J. J., Liu, K. L., Lii, C. K. (2005) Sulfur amino acids restriction induces the class of glutathione S-transferase expression in primary rat hepatocytes. Journal of Nutrition. 135,1034-1039.

Tsai, C. W., Yang, J. J., Chen, H. W., Sheen, L. Y., Lii, C. K. (2005) Garlic Organosulfur Compounds Up-Regulate the Expression of the p Class of Glutathione S-Transferase in Rat Primary Hepatocytes. Journal of Nutrition. 135, 2560-2565.

Chang, C. H., Chen, T. H., Hsu, R. C., Chou, P. H., Yang, J. J., and Hwang, G. Y. (2005) The prevalence of HPV-18 and variants of E6 gene isolated from cervical cancer patients in Taiwan. Journal of Clinical Virology. 32, 33-37.

Li, C. C., Shen, H. L. Lii, C. K. Liu, K. L. Yang, J. J., and Chen, H. W. (2005) Prostaglandin E2 down-regulation of cytochrome P-450 2B1 expression induced by phenobarbital is through EP2 receptor in rat hepatocytes. Biochemical and Biophysical Research Communications. 327, 424-430.

Huang, C. Y., Chueh, P. J., Tseng, C. T., Liu, K. Y., Tsai, H. Y., Kuo, W. W., Chou, M. Y., and Yang, J. J.* (2004) ZAKnre-programs Atrial Natriuretic Factor Expression and Induces Hypertrophic Growth in H9c2 Cardiomyoblast Cell. Biochemical and Biophysical Research Communications. 324, 973-980.

Huang, C. Y., Kuo, W. W., Chueh, P. J. Tseng, C. T., Chou, M. Y., and Yang, J. J.* (2004) Transforming Growth Factor- (TGF-ҭOnInduces the Expression of ANF and Hypertrophic Growth in Cultured Cardiomyoblast Cells through ZAK. Biochemical and Biophysical Research Communications. 324, 424-431.

Yang, L. C., Yang, S. H., Tai , K. W., Chou, M. Y., and Yang,  J. J.* (2004) MEK inhibition enhances bleomycin A5-induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities. J of Oral Pathology and Medicine. 33,37-45.

Yang, J. J.* (2003) A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle. Biochemical and Biophysical Research Communications. 301, 71-77.

Chen, H. W., Tsai, C. W., Yang, J. J., Liu, C. T., Kuoy, W. W., Lii, C. K. (2003) The combined effects of garlic oil and fish oil on the hepatic antioxidant and drug-metabolizing enzymes of rats. British J. Nutrition. 89, 189-200.

Yang, J. J.* (2002) Mixed lineage kinase ZAK utilizing MKK7 and not MKK4 to activate the c-Jun N-terminal kinase and playing a role in the cell arrest. Biochemical and Biophysical Research Communications. 297, 105-110.

Huang, T. H., Yang, J. J., Li, H., and Kao, C. T. (2002) The biocompatibility evaluation of epoxy resin-based root canal sealers in vitro. Biomaterials. 23, 77-83.

Tsai, C. F., Lii, C. K., Yang, J. J., Liu, K., Lin, W. L., and Chen, H. W. (2001) Prostaglandin E2 is involved in the increase of Cytochrome P-450 2B1 expression by -Tocophenryl Succinate in primary rat hepatocytes in the presence of Phenobarbital. Nutrition and Cancer. 41, 188-195.

Chen, H. W., Yang, J. J., Wu, J. J., Tsai, C. W., Sheen, L. Y., Ou, C. C., and Lii, C. K. (2001) Dietary fat and garlic oil respectively regulate hepatic cytochrome P450 2B1 and the placental form of GSH S-Transferase expression. J. Nutrition.  131, 1438-1443.

Liu, T. C., Huang, C. J., Chu, Y. C., Wei, C. C., Chou, C. C., Chou, M. Y., Chou, C. K., and Yang, J. J.* (2000) Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif.

Biochemical and Biophysical Research Communications. 274, 811-816.

Tai, K. W., Chou, M. Y., Hu, C. H., Yang, J. J., and Chang, Y. C. (2000) Induction of apoptosis in KB cells by pingyangmycin. Oral Oncology 36, 242-247.

Yang, J. J., Kang, J. S., and Krauss, R. S. (1998) Ras signals to the cell cycle machinery via multiple pathways to induce anchorage-independent growth. Mol. Cell. Biol. 18, 2586-2595.

Yang, J. J., and Krauss, R. S. (1997). Extracellular ATP induces anchorage independent expression of cyclin A and rescues the transformed phenotype of a ras resistant mutant cell line. J. Biol. Chem. 272, 3103-3108.

Yang, J. J., Kang, J. S., and Krauss, R. S. (1995). Transformation-restoring factor: a low molecular weight secreted factor required for anchorage-independent growth of oncogene-resistant mutant cell lines. Oncogene 10, 1291-1299.