B.S. Dept. of Biology
Ph.D. Dept. of Biochemistry
e-mail: jjyang@ csmu.edu.tw
Professor School of Dentistry,
Institute of Molecular Biology,
School of Dentistry,
Research in my lab seeks to understand how signal transduction pathways regulate cell proliferation and differentiation, and how such pathways go awry during oncogenesis. . One major focus of our work centers on a novel protein kinase, the mixed lineage kinase, designated ZAK as shown in the figure. Moreover, ZAK may specifically activate JNK and turn on NF-kB transcription factor in several cell lines. The over expression of this gene induces apoptosis in hepatoma cells.
Tsai, C. W., Chen, H, W., Yang, J. J., Liu, K. L., Lii, C. K. (2005) Sulfur amino acids restriction induces the class of glutathione S-transferase expression in primary rat hepatocytes. Journal of Nutrition. 135,1034-1039.
Tsai, C. W., Yang, J. J., Chen, H. W., Sheen, L. Y., Lii, C. K. (2005) Garlic Organosulfur Compounds Up-Regulate the Expression of the p Class of Glutathione S-Transferase in Rat Primary Hepatocytes. Journal of Nutrition. 135, 2560-2565.
Chang, C. H., Chen, T. H., Hsu, R. C.,
Chou, P. H., Yang, J. J., and Hwang, G.
Y. (2005) The prevalence of HPV-18 and variants of E6 gene isolated
from cervical cancer patients in
Li, C. C., Shen, H. L. Lii, C. K. Liu, K. L. Yang, J. J., and Chen, H. W. (2005) Prostaglandin E2 down-regulation of cytochrome P-450 2B1 expression induced by phenobarbital is through EP2 receptor in rat hepatocytes. Biochemical and Biophysical Research Communications. 327, 424-430.
Huang, C. Y., Chueh, P. J., Tseng, C. T., Liu, K. Y.,
Tsai, H. Y., Kuo, W. W., Chou, M. Y., and
Yang, J. J.* (2004) ZAKƒnre-programs Atrial Natriuretic Factor Expression and Induces
Hypertrophic Growth in H
Huang, C. Y., Kuo, W. W., Chueh, P. J. Tseng, C. T., Chou, M. Y., and Yang, J. J.* (2004) Transforming Growth Factor-ƒÒ (TGF-ƒÒOƒnInduces the Expression of ANF and Hypertrophic Growth in Cultured Cardiomyoblast Cells through ZAK. Biochemical and Biophysical Research Communications. 324, 424-431.
Yang, L. C., Yang, S. H., Tai , K. W., Chou, M. Y., and Yang, J. J.* (2004) MEK inhibition enhances bleomycin A5-induced apoptosis in an oral cancer cell line: signaling mechanisms and therapeutic opportunities. J of Oral Pathology and Medicine. 33,37-45.
Yang, J. J.* (2003) A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle. Biochemical and Biophysical Research Communications. 301, 71-77.
Chen, H. W., Tsai, C. W., Yang, J. J., Liu, C. T., Kuoy, W. W., Lii, C. K. (2003) The combined effects of garlic oil and fish oil on the hepatic antioxidant and drug-metabolizing enzymes of rats. British J. Nutrition. 89, 189-200.
Yang, J. J.* (2002) Mixed lineage kinase ZAK utilizing MKK7 and not MKK4 to activate the c-Jun N-terminal kinase and playing a role in the cell arrest. Biochemical and Biophysical Research Communications. 297, 105-110.
Huang, T. H., Yang, J. J., Li, H., and Kao, C. T. (2002) The biocompatibility evaluation of epoxy resin-based root canal sealers in vitro. Biomaterials. 23, 77-83.
Tsai, C. F., Lii, C. K., Yang, J. J., Liu, K., Lin, W. L., and Chen, H. W. (2001) Prostaglandin E2 is involved in the increase of Cytochrome P-450 2B1 expression by ƒÑ-Tocophenryl Succinate in primary rat hepatocytes in the presence of Phenobarbital. Nutrition and Cancer. 41, 188-195.
Chen, H. W., Yang, J. J., Wu, J. J., Tsai, C. W., Sheen, L. Y., Ou, C. C., and Lii, C. K. (2001) Dietary fat and garlic oil respectively regulate hepatic cytochrome P450 2B1 and the placental form of GSH S-Transferase expression. J. Nutrition. 131, 1438-1443.
Liu, T. C., Huang, C. J., Chu, Y. C., Wei, C. C., Chou, C. C., Chou, M. Y., Chou, C. K., and Yang, J. J.* (2000) Cloning and expression of ZAK, a mixed lineage kinase-like protein containing a leucine-zipper and a sterile-alpha motif.
Biochemical and Biophysical Research Communications. 274, 811-816.
Tai, K. W., Chou, M. Y., Hu, C. H., Yang, J. J., and Chang, Y. C. (2000) Induction of apoptosis in KB cells by pingyangmycin. Oral Oncology 36, 242-247.
Yang, J. J., Kang, J. S., and Krauss, R. S. (1998) Ras signals to the cell cycle machinery via multiple pathways to induce anchorage-independent growth. Mol. Cell. Biol. 18, 2586-2595.
Yang, J. J., and Krauss, R. S. (1997). Extracellular ATP induces anchorage independent expression of cyclin A and rescues the transformed phenotype of a ras resistant mutant cell line. J. Biol. Chem. 272, 3103-3108.
Yang, J. J., Kang, J. S., and Krauss, R. S. (1995). Transformation-restoring factor: a low molecular weight secreted factor required for anchorage-independent growth of oncogene-resistant mutant cell lines. Oncogene 10, 1291-1299.