Professor
B.S.
Dept. of Biology
M.S.
Ph.D.
Dept. of
Biochemistry
e-mail: jjyang@
csmu.edu.tw
Experiences:
Assistant
Professor School of Dentistry,
Assistant Professor
Institute of Molecular Biology,
Associate Professor
School of Dentistry,
Research in my lab seeks to understand
how signal transduction pathways regulate cell proliferation and
differentiation, and how such pathways go awry during oncogenesis. . One major
focus of our work centers on a novel protein kinase, the mixed lineage kinase,
designated ZAK as shown in the figure. Moreover, ZAK may specifically activate
JNK and turn on NF-kB transcription factor in several cell
lines. The over expression of this gene induces apoptosis in hepatoma
cells.
Publications:
Tsai, C. W., Chen, H,
W., Yang, J. J., Liu,
K. L., Lii, C. K. (2005) Sulfur amino acids restriction
induces the class of glutathione S-transferase expression in primary rat
hepatocytes. Journal of Nutrition. 135,1034-1039.
Tsai, C. W.,
Yang, J.
J., Chen, H. W., Sheen, L. Y.,
Lii, C. K.
(2005) Garlic Organosulfur
Compounds Up-Regulate the Expression of the p Class of Glutathione
S-Transferase in Rat Primary Hepatocytes. Journal of
Nutrition. 135, 2560-2565.
Chang, C. H., Chen, T. H., Hsu, R. C.,
Chou, P. H., Yang, J. J., and Hwang, G.
Y. (2005) The prevalence of HPV-18 and variants of E6 gene isolated
from cervical cancer patients in
Li,
C. C., Shen, H. L. Lii, C. K. Liu, K. L. Yang, J.
J., and Chen, H. W. (2005) Prostaglandin E2
down-regulation of cytochrome P-450 2B1 expression induced by phenobarbital is
through EP2 receptor in rat hepatocytes. Biochemical and
Biophysical Research Communications. 327,
424-430.
Huang, C. Y., Chueh, P. J., Tseng, C. T., Liu, K. Y.,
Tsai, H. Y., Kuo, W. W., Chou, M. Y., and
Yang, J. J.* (2004) ZAKƒnre-programs Atrial Natriuretic Factor Expression and Induces
Hypertrophic Growth in H
Huang, C. Y., Kuo, W. W., Chueh, P. J.
Tseng, C. T., Chou, M. Y., and Yang, J. J.* (2004)
Transforming Growth Factor-ƒÒ (TGF-ƒÒOƒnInduces the Expression of ANF and Hypertrophic Growth in Cultured
Cardiomyoblast Cells through ZAK. Biochemical and Biophysical Research
Communications. 324, 424-431.
Yang, L. C., Yang, S. H., Tai , K. W., Chou, M. Y.,
and Yang, J. J.* (2004) MEK inhibition enhances bleomycin
A5-induced apoptosis in an oral cancer cell line: signaling mechanisms and
therapeutic opportunities. J of Oral Pathology and
Medicine.
33,37-45.
Yang, J. J.* (2003) A novel zinc finger
protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells
re-entering the cell cycle. Biochemical and Biophysical Research
Communications. 301, 71-77.
Chen, H. W., Tsai, C. W., Yang, J.
J., Liu, C. T., Kuoy, W. W., Lii, C. K. (2003) The combined effects of
garlic oil and fish oil on the hepatic antioxidant and drug-metabolizing enzymes
of rats. British J. Nutrition. 89, 189-200.
Yang, J. J.* (2002) Mixed lineage kinase ZAK
utilizing MKK7 and not MKK4 to activate the c-Jun N-terminal kinase and playing
a role in the cell arrest. Biochemical and Biophysical Research
Communications. 297, 105-110.
Huang, T. H., Yang, J. J., Li,
H., and Kao, C. T. (2002) The biocompatibility evaluation of epoxy resin-based
root canal sealers in vitro. Biomaterials. 23, 77-83.
Tsai, C. F., Lii, C. K., Yang, J.
J., Liu, K., Lin, W. L., and Chen, H. W. (2001) Prostaglandin
E2 is involved in the increase of
Cytochrome P-450 2B1 expression by Ą-Tocophenryl Succinate in primary rat
hepatocytes in the presence of Phenobarbital. Nutrition and
Cancer. 41, 188-195.
Chen, H. W., Yang, J. J., Wu, J.
J., Tsai, C. W., Sheen, L. Y., Ou, C. C., and Lii, C. K. (2001) Dietary fat and
garlic oil respectively regulate hepatic cytochrome P450 2B1 and the placental
form of GSH S-Transferase expression. J. Nutrition.
131, 1438-1443.
Liu, T. C., Huang, C. J., Chu, Y. C.,
Wei, C. C., Chou, C. C., Chou, M. Y., Chou, C. K., and Yang, J. J.*
(2000) Cloning and expression of ZAK, a mixed lineage
kinase-like protein containing a leucine-zipper and a sterile-alpha motif.
Biochemical and Biophysical Research
Communications. 274, 811-816.
Tai, K. W., Chou, M. Y., Hu, C. H.,
Yang, J. J., and Chang, Y. C. (2000) Induction of apoptosis in KB cells
by pingyangmycin. Oral Oncology 36, 242-247.
Yang, J. J., Kang, J. S., and Krauss, R. S. (1998)
Ras signals to the cell cycle machinery via multiple pathways to induce
anchorage-independent growth. Mol. Cell. Biol. 18,
2586-2595.
Yang, J. J., and Krauss, R. S. (1997).
Extracellular ATP induces anchorage independent expression of cyclin A and
rescues the transformed phenotype of a ras resistant mutant cell line. J.
Biol. Chem. 272, 3103-3108.
Yang, J. J., Kang, J. S., and Krauss, R. S. (1995). Transformation-restoring factor: a low molecular weight secreted factor required for anchorage-independent growth of oncogene-resistant mutant cell lines. Oncogene 10, 1291-1299.