Professor and Dean,  Feng-Yih Yu                          

   Thanks for Taiwan Bio Industry Organizations-Special report  

        introduces our laboratory         

    https://taiwanbio.org.tw/zhtw/news/detail/291 (09-15-2021)                                                                 

          Professor and Dean of Medical Science and Technology, 2023. 8~

          Professor,  Department of Biomedical Sciences, 2017.8~2023.7 

          Professor and Chairman, Department of Biomedical Sciences, 2011.8 ~2017.7

          Professor, Department of Biomedical Sciences,  2006. 8~2011.7

          Associate Professor, Department of Biomedical Sciences, Chung Shan Medical University

          Assistant Professor, Department of Biomedical Sciences, Chung Shan Medical University

　     Research fellow,  Development Center for Biotechnology, Taipei, Taiwan 

   PhD, University of Wisconsin- Madison

           Major in Food Microbiology & Toxicology

           MS, National Taiwan University 

           BS,  National Taiwan University

   Department of Biomedical Sciences, Chung Shan Medical University 

             No. 110, Chien Kuo. N. Rd. Sec. 1. Taichung, Taiwan.

             Tel: 886-4-3609-5913   Fax: 886-4-24757412

            Email: fengyu@csmu.edu.tw

  Research Interests:   

   1. Production of antibodies for mycotoxins auch as Aflatoxin B1 (M1), Ochratoxin A,  

       Fumonisin B1, Citrinin,  Deoxynivenol (DON), Zearalenone and algae toxins such as

      Microcystin, Okadaic acid, Saxitoxin and Domoic acid.

   2. Production of polyclonal /monoclonal antibody production and gold nanoparticles rapid

       immunochromatographic  assay for small molecule weight toxins

   3. Production of antibodies for b-agonist Ractopamine, Clenbuterol, Salbutamol, antibiotics

       such as chloramphenicol  and florfenicol and development of nano-particles (Gold

      nanoparticles) rapid immunochromatographic assay for  these b-agonist and antibiotics

  4. Development of antibody production and enzyme immunoassay for carcinogenic

      aristolochic acid in Chinese herbal medicine

 Academic Activities:  

           Editorial Board: ISRN Toxicology (2010~)

           Editorial Board: World Scientific Journal (2013~)

           Analytica Chimica Acta (reviewer, 2012)

           Talanta (reviewer, 2012)

           Biotechnology Journal 審稿 (reviewer,2012)

           Analytical Biochemistry (reviewer, 2012)

           Journal of Agricultural and Food Chemistry (SCI) 審稿 (2013, 2012, 2011. 2010 )

           Journal of Science of Food and Agriculture (SCI) 審稿 (reviewer,2010, 2009)

           Food Chemistry (SCI) 審稿 (reviewer, 2013)

           Editor: Chung Shan Medical Journal (2005.8~2007.7)

  (A) Patent: 

    1. Inventor: Feng-Yih Yu; US patent『Monoclonal antibody Specific to ochratoxin   A』 Approval-

      2011.8.23; 2009-2029.

  (B) Publications: (* corresponding author)  

   1. Wu, S. W., Chen,Y. J. Chang Y.W., Huang, C Y, Liu, B. H., Yu, F. Y*. 2024 Novel enzyme-linked aptamer-antibody         

      sandwich assay and hybrid lateral flow strip for SARS-CoV-2 detection. Journal of Nanobiotechnology 22:5 (SCI, IF 10.2 )

   2.  Tsai, J. F., Wu, T. S., Huang, Y. T., Lin, W. J. Yu, F. Y*., Liu, B. H*., 2023 Exposure to mycotoxin citrinin promotes

       carcinogenic potential of human renal cells. Journal of Agricultural and Food Chemistry. 71:19054-19065. (SCI)

   3  Huang, C. L., Wu. S.W., Hsu, T. C., Yang, C. Y._, Chung, W-H, Lin, X. J., Liu, B.-H., Yu, F. Y* 2023. Novel      

      monoclonal antibody-based sensitive enzyme-linked immunosorbent assay and rapid  immunochromatographic strip for         

       sensitive  detecting  aristolochic acid I in herbal remedies. Microchemical Journal 191:108884 (SCI)

   4.  Tsai, J. F., Wu, T. S., Yu, F. Y*.,  Liu, B. H*. 2023. Neurotoxicity of mycotoxin citrinin: Novel evidence in

        developing  zebrafish and underlying mechanisms in human neuron cells. Food and Chemical Toxicology, 171, 113543.

         (SCI)

   5. Wu, S. W., Ko, J. L., Liu, B. H., Yu F. Y*.  2022.Pilot production of a sensitive ELISA kit and an 

        immunochromatographic strip for rapid detecting citrinin in fermented rice. RSC Advances 12:19981-19989. (SCI)

   6. Hu, R. H., Wu, C. T., Wu, T. S., Yu, F. Y., Ko, J. L. & Liu, Y. F. 2022. Systematic characterization of the group 2        

        house dust mite allergen in Dermatophagoides microceras. Frontiers in Cellular and Infection Microbiology. 11: 793559.          (SCI)  

    7. Cheng, Y. C., Wu, T. S. Huang, Y. T. Chang, Y. , Yang J. J., Yu, F. Y*.  Liu, B. H. 2021. Aflatoxin B1 interferes with

         embryonic liver development: Involvement of p53 signaling and apoptosis in zebrafish. Toxicology 458:152844-152853

   8. Wu, S. W., Ko, J. L., Liu, B. H., & Yu, F. Y.* 2020. A sensitive two-analyte immunochromatographic strip for        

       simultaneously detecting aflatoxin M1 and chloramphenicol in milk. Toxins, 12, 637-649. (SCI)

    9. Wu, T. S., Lin, Y. T., Huang, Y. T., Yu, F. Y*., & Liu, B. H.  2020. Ochratoxin A triggered intracerebral hemorrhage

      in embryonic zebrafish: Involvement of microRNA-731 and prolactin receptor. Chemosphere, 242, 125143. (SCI)

    10. Wu, S. W., Wang, M. Y., Liu, B. H., & Yu, F. Y*. 2020. Sensitive enzyme‐linked immunosorbent assay and gold         

          nanoparticle immunochromatocgraphic strip for rapid detecting chloramphenicol in food. Journal of Food Safety, 40,           

         e12759. (SCI)

   11.  Wu, T. S., Cheng, Y. C., Chen, P. J., Huang, Y. T., Yu, F. Y*., & Liu, B. H. 2019. Exposure to aflatoxin B1 interferes       

         with locomotion and  neural development in zebrafish embryos and  larvae. Chemosphere. 217, 905-913. (SCI)

   12.  Wu. S. W., Yu, Y. A., Liu, B. H., Yu, F. Y.*. 2018. Development of a sensitive enzyme-linked           

         immunosorbent assay and rapid gold nanoparticle immunochromatographic strip for detecting citrinin in Monascus             

        fermented food.  Toxins, 10, 354-367 (SCI)

   13.  Huang, Y. T., Wu, T. S., Lu, C. C., Yu, F. Y., Liu, B. H. 2018. Aristolochic acid I interferes with the expression of

           BLCAP tumor suppressor gene in human cells. Toxicology letters, 291,  129-137. (SCI)

   14. Wu, T. S., Lin, Y. T., Huang, Y. T., Cheng, Y. C., Yu, F. Y., Liu, B. H. 2018. Disruption of liver development and          

          coagulation pathway by ochratoxin A in embryonic zebrafish. Toxicology and applied pharmacology, 340, 1-8. (SCI) 

   15.  Liu, B. H.,  Chu, K. C., Yu, F. Y*. 2016. Novel monoclonal antibody-based sensitive enzyme-linked immunosorbent

          assay and rapid immunochromatographic strip for detecting aflatoxin M1 in milk.  Food Control 66:1-7(SCI)

   16.  Wu, T. S., Yang, J. J., Wang, Y. W., Yu, F. Y*., Liu, B. H*.  2016.  Mycotoxin ochratoxin A disrupts renal development

           via miR-731/prolactin receptor axis in zebrafish. Toxicology Research 5:519-529 (SCI).

   17.   Liu, J. W., Lu, C. C., Liu, B. H., Yu, F. Y.* 2016  Development of novel monoclonal antibodies-based ultrasensitive

          enzyme-linked immunosorbent assays and rapid immunochromatographic strips for aflatoxin B1 detection. Food Control  

          59:700-707.(SCI) 

   18. Tsai, H., Lu, Y. H., Liao, H. X., Wu, S. W., Yu, F. Y., Fuh, C. B. 2015. Detection of rabbit IgG by using functional

          magnetic  particles and an enzyme-conjugated antibody with a homemade magnetic microplate. Chemistry Central Journal.

          9: 8-14. (SCI)

    19.  Liu, B. H., Hung, T, C., Lu, C. C, Chou, H. N.,  Yu, F. Y*. 2014. Production of monoclonal antibody for okadaic acid

          and its utilization in an ultrasensitive enzyme-linked immunosorbent assay and one-step immunochromatographic strip

          Journal of Agricultural and Food Chemistry. 62:1254-1260. (SCI)

    20. Vdovenko, M., Lu, C. C., Yu, F. Y*., Sakharov, I.  2014. Development of ultrasensitive direct chemiluminescent

          enzyme immunoassay for determination of aflatoxin M1 in milk. Food Chemistry 158:310-314. (SCI)   

    21.  Wu, T. S.,  Yang, J. J., Yu, F. Y*.,  Liu, B. H*.  2013. Cardiotoxicity of mycotoxin citrinin and involvement of

          microRNA-138 in zebrafish embryos. Toxicological Sciences 136:402-412.  (SCI)

    22.  Vdovenko, M., Hung, C. T.,^. Sakharov, I., Yu, F. Y*  2013. Determination of okadaic acid in shellfish by

          using a novel chemiluminescent enzyme-linked immunosorbent assay method. Talanta 116:343-346. (SCI)  

   23.  Yu. F. Y., Gribas, A., Vdovenko, M., Wang, J. J., Sakharov, I.  2013.  Development of ultrasensitive direct

          chemiluminescent enzyme immunoassay for determination of aflatoxin B1 in food products.  Talanta 107:285-29. (SCI)  

   24.   Liu, B. H., Hsu, Y. T, Lu, C. C, Yu, F. Y*.  2013. Detecting aflatoxin B1 in foods and feeds by using sensitive

           rapid enzyme-linked immunosorbent assay and gold nanoparticle immunochromatographic strip.  Food Control

           30:184-189 (SCI)

   25.  Wu, T. S., Yang, J. J., Yu, F. Y*, Liu, B. H*. 2012. Evaluation of nephrotoxic effects of mycotoxins, citrinin

          and patulin on zebrafish embryos. Food Chemical Toxicology 50:4398-4404. (SCI)

   26.  Yu, F. Y., Vdovenko, M., Wang, J. J., Sakharov, I. 2011.  Comparison of enzyme-linked immunosorbent

          assays with chemiluminescent and colorimetric detection for determination of ochratoxin A in food

          Journal of Agricultural and Food Chemistry. 59:809-813.(SCI).

   27.  Wang, J. J., Liu, B. H., Hsu, Y. T., Yu, F. Y*. 2011. Sensitive enzyme-linked immunosorbent assay

          and gold  nanoparticle immunochromatographic strip for detecting aflatoxin M1 in Milk.

          Food Control. 22:954-959.(SCI) 

   28. Chang, C. H. , Yu, F. Y*., Wu, T. S. Wang, L. T., Liu, B. H.*2011. Mycotoxin citrinin induced cell cycle

         G2/M arrest and numberical chromsomal aberration associated with disruption of microtubule formation in

         human cells. Toxicological Sciences 119:84-92.(SCI)  (equal contribution to the first author)

   29. Yu, F. Y., Wu, T. S., Chen, T. W., Liu, B. H. 2011. Aristolochic acid induced oxidative DNA damage

         associated with glutathione  depletion and ERK1/2 activation in HL-60 cells.  Toxicology in vitro 25:810-816.(SCI) 

   30 . Yu, F. Y., Chu, T. Y., Lian J.D., Wu, S. W., Hung, T, W., Chang, H. R., 2011. Induction of oxidative stress

         and DNA damage in human renal proximal tubular cells by arsistolochic acid. Journal  of Food and

         Drug Analysis. (SCI) 19:114-122. 

   31.  Liu, M. C., Lin, T. H., Wu, T. S., Yu, F. Y., Lu, C. C., Liu, B. H.* 2011. Aristolochic acid I suppressed iNOS

         gene expression and NF-kappa B activation in stimulated macrophage cells. Toxicology Letters 202:93-99. SCI) (in Press)

   32. Shiu, C. M., Wang, J. J., Yu, F. Y.* 2010.  Sensitive enzyme-linked immunosorbent assay and  rapid one-step

        immunochromatographic strip for fumonisin B1 in grain based food and feed  samples.  Journal of Science of 

        Food and Agriculture 90: 1020-1026. (SCI)  

   33.  Chang,C. H. , Yu, F. Y., Lin, Y. S., Wang, L. T., Liu, B. H. 2009. Activation of ERK and JNK  signaling pathways 

         by mycotoxin citrinin in human cells. Toxicol. Appl. Pharmacol. 237 :281-287. (SCI)

   34.  Liao, Y. C., Wu, T. S., Yu, F. Y., Tsai, C. H., Liu, B. H.* 2008. Mycotoxin patulin induced apoptosis in 

          mammalian cells through a p53-independent pathway. Toxicology Letters 183:105-111. (SCI)

   35. Liu, B. H., Tsao, Z. J., Wang, J. J.,  Yu, F. Y.*  2008.  Development of a monoclonal antibody against ochratoxin A 

        and its application in enzyme-linked immunosorbent assay and gold nanoparticle immunchromatographic strip.  

        Analytical Chemistry 80: 7029-7035. (SCI, IF: 5.287)

   36. Tsao, Z. J., Liao Y. C.^,  Liu, B. H.,  Su, C. C., Yu, F. Y.* 2007. Development of a monoclonal  antibody  

         against domoic acid and its application in enzyme-linked immunosorbent  assay  and colloidal gold immunostrip.

         Journal of Agricultural and Food Chemistry 55: 4921-4927. (SCI)

   37.  Liu, B. H., Wu, T. S., Yu, F. Y., Su, C. C. 2007. Induction of oxidative stress response by the

           mycotoxin patulin in mammalian cells. Toxicological Sciences 95(2):340-347. (SCI)

   38.  Yu, F. Y*., Lin, Y. H., Su, C. C. 2006.  A sensitive enzyme-linked immunosorbent assay for detecting 

          carcinogenic aristolochic acid in in herbal remedies.  Journal of Agricultural  and Food Chemistry 54: 2496-2501. (SCI)  

   39. Liu, B. H., Wu, T. S., Yu, F. Y., Wang, C. H. 2006. Mycotoxin patulin activates p38 and   

           JNK signaling pathways in human embryonic kidney cells. Toxicological Sciences 89: 423-430. (SCI)  

   40. Yu, F. Y.*,  Liao, Y. C., Chang, C. H., Liu, B. H  2006. Citrinin induces apoptosis in HL-   

           60 cells via mitochondrial pathway. Toxicology Letters 161:  143-151. (SCI)  

   41. Yu, F. Y.*.,  T-F. Chi, B. H. Liu., Su, C. C. 2005. Development of a sensitive enzyme-linked  immunosorbent 

            assay  for the  determination of  ochratoxin A. Journal of Agricultural and Food Chemistry 53: 6947-953. (SCI)

   42. Wu, T. S., Yu, F. Y., Su, M. C., , Kan, C. C., Liu, B. H.  2005. Activation of ERK mitogen-activated protein kinase

          by mycotoxin Patulin in human cells. Toxicology and Applied Pharmacology. 207:103-111. (SCI)

   43. Liu, B. H.,  T. S. Wu,  M. C. Su, C. P. Chung,  F. Y. Yu* 2005.  Evaluation of Citrinin occurrence and cytotoxicity in

          Monascus fermentation products.   Journal of Agricultural and Food Chemistry 53:170-175. (SCI)

  44. Yu, F. Y*., B. H. Liu, T. S. Wu, T-F. Chi, M. C. Su. 2004. Development of a sensitive enzyme-linked immunosorbent 

          assay  for the  determination of  domoic acid in shellfish.  Journal of Agricultural and Food Chemistry  52: 5334-5339.

        (SCI)

  45.  Liu, B. H., F. Y. Yu, T. S. Wu, S. Y. Li, M. C. Su, M. C. Wang, and S. M. Shih. 2003. Evaluation of genetic risk and

           oxidative DNA damage in mammalian cells exposed to mycotoxins, patulin and citrinin. Toxicology and Applied

           Pharmacology. 191: 255-263.   (SCI)

  46. Liu, B. H., C. Y. Huang, F. Y. Yu, and P. C. Lin. 2003. The presence and expression of aflR gene in various Aspergillus

         species.  Food Science and Agricultural Chemistry. 4:149-155.

  47.  Yu, F. Y*., B. H. Liu, H. R. Chou, F. S. Chu. 2002. Development of a sensitive ELISA for the determination 

          of microcystins in algae. Journal of Agricultural and Food Chemistry. 50:4176- 4182.(SCI) 

  48.  Liu, B.-H*., Yu, F. Y.  M. H. Chan, and Y. L. Yang. 2002. The effects on mycotoxins,  fumonisin B1 and aflatoxin B1,

           on primary swine alveolar macrophages. Toxicology and Applied Pharmacology.180:197-204. (SCI)

  49.  Liu, B.-H., Yu, F. Y.*. 2001. DNA affinity-purified AFLR binds to the 5' upstream regions of aflatoxin pathway genes.

           Food Science and Agricultural Chemistry. 3:84-90.

  50.  Christensen, H., F.-Y. Yu, and F. S. Chu. 2000. Development of a polyclonal antibody-based sensitive Enzyme-linked

             immunosorbent assay for Fumonisin B4. Journal of Agricultural and Food Chemistry  48:1977-1984.(SCI).