許振東教授 Hsu, Jeng-Dong
Tel: 04-2473-0022 分機11625
Fax: 04-2475-3984
E-mail: dongdong@csmu.edu.tw
現職：
中山醫學大學醫學系病理學科教授
中山醫學大學附設醫院解剖病理科主治醫師兼主任
經歷：
中山醫學大學學務處課外活動組主任
中山醫學大學醫學系病理學科主任
中山醫學大學校友服務室主任
學歷：
中山醫學院牙科18屆畢業
中山醫學院牙醫學系(1986)畢業
中山醫學院醫學研究所醫學碩士
教授科目：
1.
口腔病理學
2.
病理學
3. 法醫學
研究興趣：
1.
分子毒理
2.
癌症病理
3.
口腔病理
著作：
(A) Referred Papers
1. Chau-Jong Wang, Ying-Jyh Lyan, Yuh-Shiow Fuh, Jeng-Dong
Hsu, Chia-Bin Liu, Gow-Chin Yen, Song-Jui Shiow and Jen-Kun Lin (1986)
Protective effect of Wheat –Seedling on hepatic damage induced by carbon
tetrachloride in rats. J. Chinese Nutr. Soc., 11, 19-31
2. Jeng-Dong Hsu, Wea-Lung Lin and Yih-Shyong Lai (1990) Differential diagnosis of
ossifying fibroma and fibrous dysplasia: An immunohistochemical study. Chung
Shan Med. J., 1, 33-39.
3. Chia-Yih Chu, Jeng-Dong Hsu and Chau-Jong Wang
(1991) Protective effect of San-Huang-Hsieh-Hsin-Tang on experimental hepatic
injury in rats. Chung Shan Med. J. , 2,62-71.
4. Chau-Jong Wang, Jeng-Dong Hsu and Jen-Kun Lin
(1991) Suppression of alflatoxin B1 –induced hepatic lesions by crocetin (a
natural carotenoids). Carcinogenesis, 12,1807-1810. (SCI)
5. Shaw-Win Wang, Chia-Yih Chu, Jeng-Dong Hsu and
Chau-Jong Wang (1993) Haemotoxic effect of phenylurea herbicides in rats: role
of haemoglobin-adduct formation in splenic toxicity. Fd. Chem. Toxicol.,
31,285-295. (SCI)
6. Miao-Jane Lee, Jeng-Dong Hsu and Chau-Jong Wang
(1995) Inhibition of 12-O-tetradecanoylphorbol-13-acetate-caused tumor
promotion in benzo[a] pyrene-initiated CD-1 mouse skin by geniposide.
Anticancer Res., 15:411-416. (SCI)
7. Tun-Jen Cheng, Trang-Tiau Wu and Jeng-Dong Hsu
(1995) A dumbbell spinal lipoma presenting as a neck mass: CT and MR
demonstration. Pediatr Radiol., 25:570-571. (SCI)
8. Tsui-Hwa Tseng, Jeng-Dong Hsu, Chia-Yih Chu and
Chau-Jong Wang (1996) Promotion of colon carcinogenesis through increasing
lipid peroxidation iduced in rats by a high cholesterol diet. Cancer
Letters.,100:81-87. –(SCI)
9. Yu-Ling Lin, Tsui-Hwa Tseng, Jeng-Dong Hsu, Chia-Yih
Chu and Chau-Jong Wang (1996) Hepatotoxicity of 1, 3, 5-trinitro-2-acetyl
pyrrole derived from nitrosation of Maillard reaction production in BALB/C
mouse. Toxicology Letters. , 89:169-174. (SCI)
10. Jeng-Dong Hsu, Ching –Lin Hsu, Fen-Pi Chou, Pao-Hsiang Wen and Chau-Jong Wang (1997)
Potential effect of sodium nitrite on the expression of nuclear proto-oncogenes
during 2-acetyl aminofluorene-induced hepatocarcinogenesis in rats.
Chemico-Biological Interactions., 108:1-18. (SCI)
11. Tsui-Hwa Tseng, Jeng-Dong Hsu, Ming-Hsiang Lo,
Chia-Yih Chu, Chao-Lu Huang and Chau-Jong Wang (1998) Inhibitory effect of
Hibiscus protocatechic acid on tumor promotion in mouse skin. Cancer Letters.,
126:199-207. (SCI)
12. Tsui-Hwa Tseng, Ming-Cheng Chang, Jeng-Dong Hsu,
Miao-Jane Lee, Ching-Lin Hsu, Kuang-Ping Lan and Chau–Jong Wang (1998) Tumor
promoting effect of N – nitroso-N-(2-hexanonyl ) –
13. Jeng-Dong Hsu, Fen-Pi Chou, Miao-Jane Lee, Huei-Ching Chiang, Yu-Ling Lin, Song-Jui
Shiow and Chau-Jong Wang (1999) Suppression of the TPA-Induced Expressions of
Nuclear –Protooncogenes in Mouse Epidermis by Crocetin via Antioxidant
Activity. Anticancer Res., 19:4221-4228. (SCI)
14. Fen-Pi Chou, Yu-Chuan Chu, Jeng-Dong Hsu,
Huei-Ching Chiang and Chau-Jong Wang (2000) Specific induction of glutathione
S-transferase GSTM2 subunit expression by epigallocatechin gallate
in rat liver. Biochem. Pharmacol., 60,643-650. (SCI)
15. Wen –Cheng Chang, Chang-Che Chen, Tsui-Hwa Tseng,
Hwei-Pei Huang, Jeng-Dong Hsu and Chau-Jong Wang (2000) Tumor promotion
of N –nitroso-N- (3-keto-1,2-butanediol ) –
16. Hsiu-Hsiung Lee, Song-Jui Shiow, Hung-Chi Chung,
Chih-Yang Huang, Chiann-Ling Lin, Jeng-Dong Hsu, Ling-Yuh Shyu and
Chau-Jong Wang (2000) Development of brain injury in mice by Angiostrongylus
cantonensis infection is associated with the induction of transcription factor
NF-kB, nuclear protooncogenes and protein tyrosine phosphorylation. Exp.
Parasitol., 95,200-208. (SCI)
17. Yu-Ling Lin., Jeng-Dong Hsu, Fen-Pi Chou,
Miao-Jane Lee, Song-Jui Shiow and Chau –Jong Wang (2000) Suppressive effect of
penta-acetyl geniposide on the development of γ- glutamyl transpeptidase foci induced by aflatoxin B
18. Wen–Cheng Chang, Yuan-Chih Lee,Chuen-Lan Liu, Jeng-Dong
Hsu ,Hsue-Chun Wang ,Chang-Che Chen and Chau-Jong Wang (2001)
Increased expression of iNOS and c-fos via regulation of protein tyrosine
phosphorylation and MEK1/ERK2 proteins in terminal bronchioles lesions in the
lungs of rats exposed to cigarette smoke. Arch. Toxicol.,75,28-35. (SCI)
19. Chang-Che Chen, Tsui-Hwa Tseng, Jeng-Dong Hsu, and
Chau-Jong Wang (2001) Tumor-promoting Effect of GGN-MRP Extract from the
Maillard Reaction Products of Glucose and Glycine in the Presence of Sodium
Nitrite in C3H10T1/2 Cells. J. Agric. Food Chem., 49,6063-6067. (SCI)
20. Miao-Jane Lee, Jeng-Dong Hsu, Chiann-Ling Lin,
Ming-Hsun Lin, Shu-Chuan Yuan, Chau-Jong Wang (2002) Induction of epidermal
proliferation and expressions of PKC and NF-kB by betel quid extracts in mouse;
the role of lime-piper additives in betel quid. Chemico-Biological
Interactions., 140,35-48. (SCI)
21. Yih-Shou Hsieh, Bi-Chiou Chen, Song-Jui Shiow, Hsue-Chun
Wang, Jeng-Dong Hsu, and Chau –Jong Wang (2002) Formation of
8-nitroguanine in tobacco cigarette smokers and in tobacco smoke exposed wistar
rats. Chemico-Biological Interactions., 140,67-80. (SCI)
22. Yun-Ching Chang, Tsui-Hwa Tseng, Miao-Jane Lee, Jeng-Dong
Hsu, Chau-Jong Wang (2002) Induction of apoptosis by
penta-acetyl geniposide in rat C6 glioma cells Chemico-Biological
Interactions., 141,243-257. (SCI)
23. Chang-Che Chen, Jeng-Dong Hsu, San-Fa Wang,
Huei-Ching Chiang, Mon-Yuan Yang, Erl-Shyh Kao, Yung-Chyan Ho, and
Chau-Jong Wang (2003) Hibiscus sabdariffa Extract Inhibits the
Development of Atherosclerosis in Cholesterol-Fed Rabbits., 51, 5472-5477. (SCI)
24. Yun-Ching Chang, Fen-Pi Chou, Hui-Pei Huang, Jeng-Dong
Hsu and Chau-Jong Wang (2004) Inhibition of cell cycle progression by
penta-acetyl geniposide in rat C6 glioma cells, 198, 11-20. (SCI)
25. Liu JY, Chen CC, Wang WH, Hsu JD, Yang MY, Wang
CJ. The protective effects of Hibiscus sabdariffa extract on CCl4-induced liver
fibrosis in rats. Food Chem Toxicol. (2006) 44(3):336-43.
26. Young SC, Wang CJ, Hsu JD, Hsu JL, Chou FP. Increased
sensitivity of Hep G2 cells toward the cytotoxicity of cisplatin by the
treatment of piper betel leaf extract. Arch Toxicol. (2006)
80(6):319-27.
27. Luh SP, Hsu JD, Lai YS, Chen SW. Primary
tuberculous infection of breast: experiences of surgical resection for aged
patients and review of literature. J
28. Luh SP, Chang KJ, Cheng JH, Hsu JD, Huang CS.
Surgical Treatment for Primary Mammary Tuberculosis—Report of Three
Octogenarian Cases and Review of Literature. Breast J. (2008)
14(3):311-2.
29. Chen JH, Lin HH, Chiang TA, Hsu JD, Ho HH, Lee YC,
Wang CJ. Gaseous nitrogen oxide promotes human lung cancer cell line A549
migration, invasion, and metastasis via iNOS-mediated MMP-2 production. Toxicol
Sci. (2008) Dec;106(2):364-75.
30. Han CP, Lee MY, Tyan YS, Kok LF, Yao CC, Wang PH, Hsu
JD, Tseng SW. p16(INK4) and CEA can be mutually exchanged with confidence
between both relevant three-marker panels (ER/Vim/CEA and ER/Vim/p16(INK4)) in
distinguishing primary endometrial adenocarcinomas from endocervical
adenocarcinomas in a tissue microarray study. Virchows Arch.
(2009) Oct;455(4):353-61. (corresponding author)
31. Hsu JD, Kao SH, Tu
CC, Li YJ, Wang CJ., Chau-Jong Solanum nigrum L extract inhibits
2-acetylaminofluorene-induced hepatocarcinogenesis through overexpression of
glutathione S-transferase and antioxidant enzymes. J Agric Food Chem. (2009)
57, 8628-8634
32. Lee WC, Wang CJ, Chen YH, Hsu JD, Cheng
SY, Chen HC, Lee HJ. Polyphenol Extracts from Hibiscus
sabdariffa Linnaeus Attenuate Nephropathy in Experimental Type 1 Diabetes. J
Agric Food Chem. (2009) Mar 25;57(6):2206-10.
33. Koo CL, Kok LF, Lee MY,Wu TS, Cheng YW, Hsu JD,
Ruan A,Chao KC, Han CP. Scoring mechanisms of p16INK
34. Kao ES, Hsu JD, Wang CJ, Yang SH, Cheng SY, Lee
HJ. Polyphenols extracted from Hibiscus sabdariffa L. inhibited
lipopolysaccharide-induced inflammation by improving antioxidative conditions
and regulating cyclooxygenase-2 expression. Biosci Biotechnol Biochem.
(2009) Feb;73(2):385-90. (equal contribution to 1st author)
35. Han CP, Hsu JD,
36. Wu CH, Shih YW, Chang CH, Ou TT, Huang CC, Hsu JD,
Wang CJ. EP(4) upregulation of Ras signaling and feedback regulation of Ras in
human colon tissues and cancer cells. Arch Toxicol. 2010 Jun 23.
37. Hsu JD, Yao CC, Yuan
CC, Lai CR, Ting LT, Li YJ, Han CP. Anti-Cytokeratin CAM5.2 (BD) does not act as a
substitute of the CK8/18 monoclonal antibody. Comment on: ‘Expression of c-MET,
low-molecular-weight cytokeratin, matrix metalloproteinases-1 and -2 in spinal
chordoma’. Histopathology. (2010) May;56(6):810;
38. Liao CL, Tzeng SL, Hsu JD, Chen PJ, Han CP. BD
(Becton, Dickinson and Company) Biosciences manufactures anticytokeratin
CAM5.2, not CK8/18 monoclonal antibody. Pathol Int. (2010)
May;60(5):417 (equal contribution to 1st author)
39. Cheng WC, Hsu JD,
40. Wu YL, Huang YF, Hsu JD, Han CP. Becton Dickinson
Biosciences CAM5.2 does not stand for true CK8/18. Comment on 『Peripheral ameloblastoma in-situ: an evidential fact of
surface epithelium origin』, Oral Surg Oral Med
Oral Pathol Oral Radiol Endod. (2010)May;109(5):655-6. (equal
contribution to 1st author)
41. Hsu JD, Yao CC, Lee
MY, Kok LF, Wang PH, Tyan YS, Han CP. True cytokeratin 8/18
immunohistochemistry is of no use in distinguishing between primary
endocervical and endometrial adenocarcinomas in a tissue microarray study. Int
J Gynecol Pathol. (2010) May;29(3):282-9.
42. Hsu JD, Han CP.
Anti-Cytokeratin CAM 5.2 (Becton Dickinson) is not synonymous with CK8/18
monoclonal antibody. Comment on 『Pancreatic-type
mixed acinar-endocrine carcinoma with alpha-fetoprotein production arising from
the stomach: a report of an extremely rare case. Med Mol Morphol. (2010)
Mar;43(1):65.
43. Han CP, Hsu JD, Koo CL, Yang SF. Antibody to
cytokeratin (CK8/CK18) is not derived from CAM5.2 clone, and anticytokeratin
CAM5.2 (Becton Dickinson) is not synonymous with the antibody (CK8/CK18). Hum
Pathol. (2010) Apr;41(4):616-7. (equal contribution to 1st author)
44. Liao CL, Hsu JD, Lee MY, Kok LF, Li YJ, Wang PH,
Yao CC, Han CP. Distinguishing between primary endocervical and endometrial
adenocarcinomas: is a 2-marker (Vim/CEA) panel enough? Virchows Arch.
(2010) Apr;456(4):377-86. (equal contribution to 1st author)
45. Chen JT, Hsu JD, Yao CC, Han LW, Han CP.
Anti-cytokeratin
46. Chen PJ, Hsu JD, Han CP. Anti-cytokeratin CAM 5.2
is specific for K8 and to a lesser extent for the closely related K7, but shows
no reactivity with K18 or K19: comment on: 『keratin expression in endocrine organs and their neoplasms』 Endocr Pathol. 2009 Spring; 20(1):1-10. Endocr Pathol.
(2010) Mar;21(1):69-70. (equal contribution to 1st author)
47. Han CP, Hsu JD, Li YJ Anticytokeratin CAM5.2 is
not synonymous with CK8/18 monoclonal antibody; and anticytokeratin CAM5.2 can
be a marker for cytokeratin 8 but not for cytokeratin 18 and 19. Am J
Surg Pathol. (2010) Apr;34(4):595. (equal contribution to 1st author)
48. Hsu JD, Yao CC, Han
LW, Han CP. CAM5.2 is not identical to cytokeratins 8 and 18. Am J Clin
Pathol. (2010) Mar;133(3):514.
49. Hsu JD, Yao CC, Han
LW, Han CP. Anti-cytokeratin CAM5.2 is not a monoclonal antibody against
cytokeratin 8/18. Clin Exp Dermatol. (2010) Mar 23
50. Wang KC, Hsu JD, Yao CC, Han CP. CAM5.2 (Becton
51. Wu TT, Tsai TW, Shen YT, Hsu JD, Yang LC, Li C
Analyses of PRMT1 proteins in human colon tissues from Hirschsprung disease
patients. Neurogastroenterol Motil. (2010) May 24.
52. Liu LC, Wang CJ, Lee CC, Su SC, Chen HL, Hsu JD,
Lee HJ. Aqueous extract of Hibiscus sabdariffa L. decelerates
acetaminophen-induced acute liver damage by reducing cell death and oxidative
stress in mouse experimental models. J Sci Food Agric. (2010) Jan
30;90(2):329-37.
專業組織：
1.
台灣病理學會會員
2.
中華民國口腔病理學會會員
3. 行政院衛生署口腔病理專科醫師
興趣組織：
1.
台灣謎學研究會
2. 台中縣謎學研究會
update:2011/04/27