Chien-Hong Chen

Associate Professor

E-mail: cchwind@csmu.edu.tw
Tel:886-4-24730022-12219 or 11892

Fax:886-4-23248189

          

Research Field

Inorganic Chemistry, Organometallics, and Bioinorganic Chemistry

 

Education          

Sep. 2002-Jul. 2005 – Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan

u        Ph.D., Major: Bioinorganic Chemistry

u        Advisor: Prof. Wen-Feng Liaw

u        Thesis Title: “Small Molecule Models of [NiFe] Hydrogenase and Nitrile Hydratase Active-sites”

Sep. 1996-Jun. 1998 – Graduate Institute of Science Education, National Changhua University of Education, Changhua, Taiwan

u   MS, Major: Inorganic Chemistry

u   Advisor: Prof. Wen-Feng Liaw

u   Thesis Title: “Iron-, and Nickel-Chalcogenolate Chemistry: Synthesis, Reactivity, and    Application”

Sep. 1992-Jun. 1996 – Department of Chemistry, National Changhua University of Education, Changhua, Taiwan

u   BS, Major: Chemistry

 

Experience

Feb. 2011- present –Associate Professor, School of Applied Chemistry, Chung Shan Medical University

　

Aug. 2006- Jan. 2011 –Assistant Professor, School of Applied Chemistry, Chung Shan Medical University

         

Dec. 2005- Jul. 2006 – Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan

u        Post-doctoral fellow in Prof. Wen-Feng Liaw’s Lab

u        Supported by National Science Council (Taiwan)

　

Sep. 2005-Nov. 2005 – Research Center for Materials Science, Nagoya University, Nagoya, Japan

u        Post-doctoral fellow in Prof. Kazuyuki Tatsumi’s Lab

Sep. 2002-Jul. 2005 – Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan

u        Research Assistant in Dr. Wen-Feng Liaw’s lab

Aug. 2001-Jul. 2002 – Yong Fu Elementary School, Taipei Country, Taiwan

u        Elementary School Teacher

Apr. 2000-Jul. 2001 – Department of Chemistry, National Changhua University of Education, Changhua, Taiwan

u        Research Assistant in Dr. Wen-Feng Liaw’s lab

u        Supported by National Science Council (Taiwan)

 

Sep. 2000-Jul. 2001 – Nan Kai Institute of Technology, Nantou, Taiwan

u        General Chemistry Lecturer (part time)

Jul. 1998-Apr. 2000 – National Military Service, Ma Zu, Taiwan

Sep. 1996-Jun. 1998 – Department of Chemistry, National Changhua University of Education, Changhua, Taiwan

u        MS Research in Dr. Wen-Feng Liaw’s lab

Research Interest

▲ The syntheses of structural models of nickel-containing enzymes and nitrile hydratases.

▲ The functional models utilizing small synthesized molecules for better understanding the mechanism of the reaction catalyzed by the metalloenzymes.

▲  The studies of transition-metal nitrosyl complexes serving as the NO donating reagents.

　

Publications

1.    Jheng-Hong Wang, and Chien-Hong Chen*. “New Members of the {Fe(NO)2}10 Dinitrosyliron Complexes Bound with [Thiolate, Thiolate] and [Amide, Amide] Ligations” Inorg. Chem. 2010, 49, 7644-7646. (IF: 4.657  D3/44; 6.8%)

2.    Chien-Hong Chen, and Wen-Feng Liaw. “IRON–CYANOCARBONYL COMPLEXES [PPN][Fe(CO)4(CN)] AND [PPN][FeBr(CO)3(CN)2]” Inorganic Syntheses 2010, 35, 129-132.

3.    Chien-Ming Lee,* Chien-Hong Chen, Fu-Xing Liao, Ching-Han Hu, and Gene-Hsiang Lee. “Mononuclear NiIII-Alkyl Complexes (Alkyl = Me and Et): Relevance to the Acetyl-CoA Synthase and Methyl-CoM Reductase” J. Am. Chem. Soc. 2010, 132, 9256-9258. (IF: 8.580  D7/138)

4.    Chien-Hong Chen*, Show-Jen Chiou*, Hsuan-Yin Chen. “Dinuclear [{Fe(NO)2}10-{Fe(NO)2}10] Dinitrosyl Iron Complex withThiolate-CO-Bridged Ligands” Inorg. Chem. 2010, 49, 2023-2025. (IF: 4.657  D3/44; 6.8%)

5.    Chien-Hong Chen, Chang-Chih Hsieh, Hon Man Lee, and Yih-Chern Horng*. “trans-Diacetonitriletetrakis(1H-pyrazole-kN2)nickel(II) dinitrate” Acta Crystallogr., Sect. E: Struct. Rep. Online 2009, E65, m1680 (IF: 0.411  D24/25; 96%)

6.    Chien-Hong Chen*, Yi-Chieh Ho, and Gene-Hsiang Lee. “Synthesis and Reactivity of the Five-coordinate {Fe(NO)2}9 [(TMEDA)Fe(NO)2I]” J. Organomet. Chem. 2009, 694, 3395-3400. (IF: 2.347  D14/44; 31.8%)

7.    Chien-Hong Chen, Gene-Hsiang Lee, and Wen-Feng Liaw＊. “Mononuclear [Ni = 2 \* ROMAN II(L)(P-(o-C6H4S)2(o-C6H4SH))]0/1–  (L = Thiolate, Selenolate, PPh3, and Cl) Complexes with Intramolecular [Ni－S…H－S]/[Ni…H－S] Interactions Modulated by the Coordinated Ligand L: Relevance to the [NiFe] Hydrogenases” Inorg. Chem. 2006, 45, 2307-2316. (IF: 4.657  D3/44; 6.8%)

8.    Chien-Ming Lee, Chien-Hong Chen, Hao-Wen Chen, Jo-Lu Hsu, Gene-Hsiang Lee, and Wen-Feng Liaw＊. “Nitrosylated Iron-Thiolate-Sulfinate Complexes with {Fe(NO)}6/7 Electronic Cores: Relevance to the Transformation between the Active and Inactive NO-Bound Forms of Fe-Containing Nitrile Hydratases” Inorg. Chem. 2005, 44, 6670-6679. (IF: 4.657  D3/44; 6.8%)

9.    Chien-Ming Lee, Chien-Hong Chen, Shyue-Chu Ke, Gene-Hsiang Lee and Wen-Feng Liaw＊. “Mononuclear Nickel(III) and Nickel(II) Thiolate Complexes with Intramolecular S-H Proton Interacting with Both Sulfur and Nickel: Relevance to the [NiFe]/[NiFeSe] Hydrogeanses” J. Am. Chem. Soc. 2004, 126, 8406-8412. (IF: 8.580  D7/138)

10.  Chien-Hong Chen, Yung-Su Chang, Chien-Yeh Yang, Tai-Nan Chen, Chien-Ming Lee and Wen-Feng Liaw＊. “Preparative and Structural Studies on Iron(II)-Thiolate Cyanocarbonyls: Relevance to the [NiFe]/[Fe]-Hydrogenases” Dalton Trans. 2004, 137-143. (IF: 4.081  D7/44; 15.9%)

11.  Chien-Hong Chen, Li-Chun Wang and Wen-Feng Liaw＊. “Preparative and Structural Studies on Ruthenium( = 2 \* ROMAN II)-Thiolate Cyanocarbonyls: Comparision to the [Fe(CO)x(CN)y(SR)z]n- Coordination Modes of Active Sites of Hydrogenases” J. Chin. Chem. Soc. 2004, 51, 1121-1126. (IF: 0.653  D96/138; 69.6%)

12.  Chien-Ming Lee, Chien-Hong Chen, Chung-Hung Hsien, Amitava Dutta and Gene-Hsiang Lee. “Iron-Nitrosyl Sulfinate Complexes: Relevance to the Fe-Containing Nitrile Hydratatses” J. Inorg. Biochem. 2003, 96, 176. (IF: 3.252  D9/44; 20.5%)

13.  Chien-Hong Chen, Chien-Ming Lee, Chung-Hung Hsieh and Wen-Feng Liaw＊. “Bioinorganic Chemistry” Chemistry (The Chinese Chem. Soc., Taipei) 2003, 61, 79-86.

14.  Wen-Feng Liaw＊, Jiun-Hung Lee, Hung-Bin Gau, Chien-Hong Chen, Shiou-Ju Jung, Chen-Hsiung Hung, Wen-Yuan Chen, Ching-Han Hu and Gene-Hsiang Lee. “Five-Coordinate and Six-Coordinate FeII(CN)2(CO)x-Thiolate Complexes (x=1, 2): Synthetic Advances for Iron Sites of [NiFe] Hydrogenases” J. Am. Chem. Soc. 2002, 124, 1680-1688. (IF: 8.580  D7/138)

15.  Wen-Feng Liaw＊, Chien-Hong Chen, Chien-Ming Lee, Gene-Hsiang Lee and Shie-Ming Peng. “Distorted Square Planar Nickel(II)-Carbonyl Complexes Containing Terminal Thiolate/Selenolate Ligands” J. Chem. Soc., Dalton Trans. 2001, 138-143. (IF: 4.081  D7/44; 15.9%)

16.  Wen-Feng Liaw＊, Jiun-Hung Lee, Hung-Bin Gau, Chien-Hong Chen, and Gene-Hsiang Lee. “Synthesis and Reactivity of fac-[Fe(CO)3(SR)3]- (R= C7H4SN, C4H3S, C4H2O-o-CH3) and Heterotrmetallic Fe(II)-Ni(II)-Fe(II) Thiolate Complexes” Inorg. Chim. Acta 2001, 322, 99-105. (IF: 2.322  D17/44; 38.6%)

17.  Wen-Feng Liaw＊, Jiun-Hung Lee, Hung-Bin Gau, Chien-Hong Chen, Shiou-Ju Jung, Wen-Yuan Chen, Ching-Han Hu, and Chen-Hsiang Hung. “Five-Coordinate and Six-Coordinate FeII(CN)2(CO)x-Thiolate Complexes (x=1, 2): Synthetic Advances for Iron Sites of [NiFe] Hydrogenases” J. Inorg. Biochem. 2001, 86, 315. (IF: 3.252  D9/44; 20.5%)

18.  Wen-Feng Liaw＊, Nan-Hung Lee, Chien-Hong Chen, Chien-Ming Lee, Gene-Hsiang Lee and Shie-Ming Peng. “Dinuclear and Mononuclear Iron(II)-Thiolate Complexes with Mixed CO/CN- Ligands: Synthetic Advances for Iron Sites of [Fe]-only Hydrogenases” J. Am. Chem. Soc. 2000, 122, 488-494. (IF: 8.580  D7/138)

19.  Wen-Feng Liaw＊, Chien-Hong Chen, Chien-Ming Lee, Ging-Yi Lin, Chao-Yi Ching, Gene-Hsiang Lee and Shie-Ming Peng. “Heterotrinuclear Complexes Containing a Hexa-selenolate-zinc(II), -cadmium(II), -nickel(II) and –iron(II) Core Individually: Crystal Structures of [(CO)3Fe(μ-SePh)3M(μ-SePh)3Fe(CO)3] (M=Zn, Cd, Ni, Fe) and [Fe(CO)2(phen)(SePh)2] (phen= 1, 10-phenanthroline)” J. Chem. Soc., Dalton Trans. 1998, 353-358. (IF: 4.081  D7/44; 15.9%)

20.  Wen-Feng Liaw＊, Chien-Hong Chen, Gene-Hsiang Lee, Shie-Ming Peng. “The Interconversion of Complexes [Fe(CO)4(SC5H4N)]-, cis-Fe(CO)2(SC5H4N)2, and [Fe(SC5H4N)3]-“ Organometallics 1998, 17, 2370-2372. (IF: 4.204  D4/44; 9.1%)

Proposals

l       Proposal for National Science Council

   ¨The NO-donor and NO disproportionation chemistry of Mn-/Fe-containing nitrosyl complexes (1/2) (95-2120-M-040-001-) 2006/10/01 ~ 2007/07/31

    ¨The NO-donor and NO disproportionation chemistry of Mn-/Fe-containing nitrosyl complexes (2/2) (96-2113-M-040-001-) 2007/08/01 ~ 2008/07/31

    ¨Synthesis and Reactivity of Fe-/Mn-containing Nitrosyl Complexes: Relevance to the NO-donor and NO Disproportionation Chemistry  (97-2113-M-040-002-MY2)  2008/08/01 ~ 2010/07/31

    ¨Synthesis, Characterization, and Reactivity of Dinitrosyl Iron Complexes (DNICs): Relevance to Nitric Oxide Delivery Reagents (99-2119-M-040-001-) 2010/08/01 ~ 2011/07/31

    ¨ Syntheses, Structures, Reactivities and Electronic Structures of Novel Dinitrosyl Iron Complexes (DNICs) (100-2113-M-040-004-MY2) 2011/08/01 ~ 2013/07/31

Awards

l   Phi Tau Phi Honor membership, National Changhua University of, 1998.