劉秉慧 教授
劉秉慧 教授
(Dr. Biing-Hui Liu)
聯絡地址:中山醫學大學生物醫學科學系
台中市建國北路一段110號 研究大樓 504室
Tel:(04)2473-0022 ext 11815
Fax:(04)2475-7412 E-mail:bingliu@csmu.edu.tw
學歷:
美國威斯康辛大學麥迪生校區,分子及環境毒理學博士,
1996
台灣大學生化科學碩士, 1990
台灣大學農化系學士, 1988
中山醫學大學生命科學系副教授, 2002.8- 2006.5
中山醫學大學生命科學系助理教授, 2000- 2002.7
慈濟大學毒理學研究所助理教授,
1999-2000
專長及教授領域:
- 利用細胞及動物模式探討天然毒素(黴菌毒素,藻類毒素)
的生化,毒理,及致癌機轉
- 針對食品及飲水中天然毒素開發免疫化學相關的檢測方法
97-100 年度(國科會 NSC 97-2313-B-040-004)
題目: 利用細胞及動物模式探討黴菌毒素Patulin之毒理機轉
95-96 年度(國科會 NSC 93-2313-B-040-003; 20040801∼20050731)
題目: 黴菌毒素Patulin誘發之訊號傳遞對細胞毒性的影響)
93-94 年度(國科會 NSC 93-2313-B-040-003; 20040801∼20050731)
題目: 黴菌毒素Patulin誘發之訊號傳遞對細胞毒性的影響
92 年度(國科會 NSC 92-2313-B-040-004;
20030801∼20040731)
題目: 致癌黴菌毒素對於細胞基因表現及訊號傳遞的影響
92 年度(衛生署; DOH
92-TD-1078; 20030101∼20031231)
題目:
紅麴產品中橘黴素citrinin的安全性評估
91 年度(國科會 NSC 91-2313-B-040-002;
20020801∼20030731)
題目: 黃麴毒素調控蛋白質AFLR的表達、純化及羧基端功能之探討
- 衛生署TFDA食品實驗室認證審議委員(2011-2012)
- 衛生署藥檢局委託檢驗機構審議委員(2009-2010)
- 教育部2010-2013 "獎勵大學實施特殊優秀人才方案'
- 98年度”國科會大專生專題研究創作獎”指導教授
- 2011年亞太糧肥中心國際會議(泰國)應邀演講
- 2010年莫斯科大學Department of Chemical Enzymology 邀請訪問演講
- 國科會2009-2013台灣-俄羅斯國際合作雙邊計畫
(NSC 98-2923-B-040-001-MY2)共同主持人
- 2006年美國威斯康辛大學Department of Pharmaceutical
Sciences訪問學者三個月
- 2011 SCI期刊審稿- Apoptosis; Free radical biology and medicine
- 2010 SCI期刊審稿 -Toxicology; J.Agric.Food Chemistry;
Food and Chemical Toxicology
- 2009 SCI期刊審稿 -Toxicon; Archives of Toxicology; Mycopathologia
Cell biology International
- 2004-2008 SCI期刊審稿 Toxicol.Appl.Pharmacol.; Acta Pharmacologica Sinica
J.of Food and Drug Analysis; Biotechnology Progress;
Pharmacological Research
Chang, C. H., Yu, F. Y., Wu, T. S., Wang, L. T., Liu, B. H*. 2011.Mycotoxin Citrinin induced cell
cycle G2/M arrest and numerical chromosomal aberration associated with disruption of microtubule
formation in human cells Toxicological Sciences 119: 84-92 (Impact Factor 5.1, ranking 3.6%)
Liu, M. C, Lin, T. H., Wu, T. S., Lu, C. C., Liu, B. H.* 2011. Aristolochic acid I suppressed iNOS gene
expression and NF-kB activation in stimulated macrophage cells. Toxicology Letter 202 : 93-99.
(Impact Factor 3.6,
領域排名17/83,
20.5 %)
Yu, F. Y., Wu, T. S., Chen, T. W., Liu, B. H*., 2011. Aristolochic acid I induced oxidative DNA damage
associated with glutathione depletion and ERK1/2 activation in human cells. Toxicology in vitro 85: 810-816
Liu, B. H, Chi J.-Y., Hsiao Y.-W.,Tsai, K.-D.., Lee Y.-J.., Lin C.-C, Hsu S.-C., Yang S.-M.,
Lin, T. H*. 2010. The fungal metabolite, citrinin, inhibits LPS/IFN-induced nitric oxide production
in glomerular mesangial cells. Int. Immunopharmacol. 10: 1608-1615
Chang,C. H. , Yu, F. Y., Lin, Y. S.,, Wang, L. T., Liu, B. H*., 2009. Activation of ERK and JNK
signaling pathways by mycotoxin citrinin in human cells. Toxicol. Appl. Pharmacol. 237, 281-287
(Impact Factor 4.0, ranking 12%)
Wu, T. S., Liao, Y. C., Chang, C. H., Liu, B. H.* 2008. Mechanism of patulin-induced apoptosis in
human leukemia cell. Toxicology letter
Liu, B. H., Tsao, Z. J., Wang, J. J., Yu, F. Y. 2008. Development of a monoclonal antibody against OTA
and its application in gold nanoparticle immunochroimatograpyic strip. Analytical Chemistry, 80,
7029-7035 (Impact Factor 5.8 , ranking 3.0 %)
Liu, B. H.*, Wu, T. S., Yu, F. Y., Su, C. C. 2007. Induction of oxidative stress response by the mycotoxin
patulin in mammalian cells. Toxicological Sciences 95 (2): 340-347. (Impact Factor 5.1, ranking 3.6%)
Liu, B. H*. Wu, T. S., Wang, C. H. 2006. Mycotoxin patulin activates p38 and JNK signaling pathways in
human embryonic kidney cells. Toxicological Sciences 89: 423-430 (SCI) (Impact Factor 5.1, 3.6%)
Yu, F. Y., Liao, Y. C., Chang, C. H., Liu, B. H*. 2006. Citrinin induces apoptosis in HL-60 cells via
activation of the mitochondrial
pathway. Toxicology Letter. 161: 143-151 (SCI)
Yu, F. Y.*, CHI, T. F., Liu, B. H., Su, M. C. 2005. Development of a Sensitive Enzyme-Linked
Immunosorbent Assay for the Determination of Ochratoxin A. J. of Agricultural and Food Chem.
53: 6947-6953. (Impact Factor 2.8, ranking 8.4 %)
Wu, T. S., Yu, F. Y., Su, M. C., , Kan, C. C., Liu, B. H*. 2005. Activation of ERK mitogen-activated protein
kinase by mycotoxin Patulin in human cells. Toxicology and Applied Pharmacology 207: 103-111. (SCI)
(Impact Factor 4.0, ranking 12%)
Liu, B. H., Wu, T. S., Su, M. C., Chung, C. P., Yu, F. Y*. 2005. Evaluation of Citrinin Occurrence and
Cytotoxicity in Monascus Fermentation Products. J. of Agricultural and Food Chem. 53: 170-175. (SCI)
Yu, F. Y., Liu, B. H., Wu, T. S., Chi, T. F., Su, M. C. 2004. Development of a sensitive enzyme-linked
immunosorbent assay for the determination of domoic acid in shellfish. Journal of Agricultural and
Food Chemistry 52: 5334-5339. (SCI)
Liu, B. H.*, F. Y. Yu, T. S. Wu, S. Y. Li, M. C. Su, M. C. Wang, and S. M. Shih. 2003. Evaluation
of genetic risk and oxidative damage in mammalian cells exposed to mycotoxins, patulin and citrinin.
Toxicology and Applied Pharmacology. 191: 255-263. (SCI)
Liu, B. H.*, C. Y. Huang, F. Y. Yu, and P. C. Lin. 2003. The prescence and expression of aflR gene
in various Aspergillus species. Food Science and Agricultural Chemistry. 4: 149-156.
Liu, B. H.*, F. Y. Yu, M. H. Chan, and Y. L. Yang. 2002. The effect on mycotoxins, fumonisins B1 and
aflatoxin B1, on primary swine alveolar macrophages. Toxicology and Applied Pharmacology.
180:197-204. (SCI)
Yu, F. Y., B. H. Liu, H. N. Chou, and F. S. Chu. 2002. Development of a sensitive ELISA for determination
of microcystins in algae. Journal of Agricultural and Food Chemistry 50: 4176-4182. (SCI)
Liu, B.-H., F.-Y. Yu*. 2001. DNA affinity-purified AFLR binds to the 5' upstream regions of aflatoxin
pathway genes. Food Science and Agricultural Chemistry.3: 84-90.
Li, T-Y., B. H. Liu, and Y. C. Chen. 2000. Characterization of Aspergillus spores by matrix-assisted
laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 14:2393-2400 (SCI)
Liu, B. H., F. Y. Yu, X. Huang, and F. S. Chu. 2000. Monitoring of Microcystin-protein phosphatase
adduct formation with immunochemical methods. Toxicon 38: 619-632. (SCI)
Liu, B. H., Bhatnagar, D., and F. S. Chu. 1999. Isolation and characterization of sterigmatocystin
O-methyltransferase involved in aflatoxin biosynthesis. Natural Toxins 7(4): 1-7
Liu, B. H., and F. S. Chu. 1998. Regulated expression of aflR and its product, AFLR, associated with
aflatoxin biosynthesis. Applied and Environmental Microbiology 64 (10) : 3718-3723.(SCI)
Liu. B. H., J. F. Brewer, J. E. Flahery, G. Payne, D. Bhatnagar, and F. S. Chu. 1997. Immunochemical
identification of AFLR, a regulatory protein, Food and Agricultural Immunology 9: 289-298.(SCI)
Liu, B. H., and F. S. Chu. 1997. Production and characterization of monoclonal antibodies against
sterigmatocystin O-methyltransferase. Food and Agricultural Immunology 9: 167-176. (SCI)
Liu, B. H., F. Y. Yu, and F. S. Chu. 1996. Anti-idiotype and anti-anti- idiotype antibodies generated
from polyclonal antibodies against microcystin-LR. Journal of Agricultural and Food Chemistry
44: 4037-4042.(SCI)
Liu, B. H., N. C. Keller, D. Bhatnagar, T. E. Cleveland, and F. S. Chu. 1993. Production and
characterization of antibodies against sterigmatocystin O-methyltransferase. Food and
Agricultural Immunology 5:155-164. (SCI)
Yuan J. N., B. H. Liu, H. Lee, Y. T. Shaw, S.T. Ch iou, W. C. Chang, and M. D. Lai. 1993. Release
of the p-53-induced repression on thymidine kinase promoter by single p53-binding sequence.
Biochemical and Biophysical Research Communication. 191(2): 662-668. (SCI)
Wang S. L., J. D. Huang, M. D. Lai, B. H. Liu, and M.L. Lai. 1993. Molecular basis of genetic varation
in debrisoquin hydroxylation in Chinese subjects:Polymorphism in RFLP and DNA sequence of
CYP2D6. Clinical Pharmacology & Therapeutics 53(4):412-418. (SCI)