Biing-Hui Liu                        

  Professor, Department of Biomedical Sciences 

           Chung Shan Medical University. 

PhD, University of Wisconsin- Madison, 1996

      Major in Environmental Toxicology, Minor in Biochemistry

  Email: bingliu@csmu.edu.tw

  Research Interests:

     Molecular and toxicological mechanisms of cellular response to mycotoxin (aflatoxins,

       fumonisins, patulin and citrinin) stress; regulatory mechanism involved in aflatoxin

       biosynthetic pathway; immunochemical detection of mycotoxins in environmental samples  

  Publications:       (* corresponding author)

Liu, B. H.*, Wu, T. S., Yu, F. Y., Su, C. C. 2007. Induction of oxidative stress response by the

     mycotoxin patulin in mammalian cells. Toxicological Sciences (In press, doi: 10.1093/toxsci/kfl 156).

Liu, B. H*. Wu, T. S., Wang, C. H. 2006. Mycotoxin patulin activates p38 and JNK signaling pathways in 

    human embryonic kidney cells. Toxicological Sciences 89: 423-430 (SCI)

Yu, F. Y.,  Liao, Y. C., Chang, C. H., Liu, B. H*. 2005. Citrinin induces apoptosis in HL-60 cells via

    activation of the mitochondrial pathway. Toxicology Letter. 161: 143-151 (SCI)

Yu, F. Y.,*, CHI, T. F., Liu, B. H., Su, M. C. 2005^. Development of a Sensitive Enzyme-Linked 

     Immunosorbent Assay for the Determination of Ochratoxin A. J. of Agricultural and Food Chem. 53: 6947-6953

 Wu, T. S., Yu, F. Y., Su, M. C., , Kan, C. C., Liu, B. H*. 2005. Activation of ERK mitogen-activated protein 

          kinase by mycotoxin Patulin in human cells. Toxicology and Applied Pharmacology 207: 103-111. (SCI)

  Liu, B. H., Wu, T. S., Su, M. C., Chung, C. P., Yu, F. Y. 2004. Evaluation of Citrinin Occurrence and

          Cytotoxicity in Monascus Fermentation Products.  J. of Agricultural and Food Chem. 53: 170-175. (SCI) 

 Yu, F. Y., Liu, B. H., Wu, T. S., Chi, T. F., Su, M. C. 2004. Development of a sensitive enzyme-linked 

           immunosorbent assay for the determination of domoic acid in shellfish. Journal of Agricultural and 

           Food Chemistry 52: 5334-5339. (SCI)   

Liu, B. H.*, F. Y. Yu, T. S. Wu, S. Y. Li, M. C. Su, M. C. Wang, and S. M. Shih. 2003. Evaluation 

          of genetic risk and oxidative damage in mammalian cells exposed to mycotoxins, patulin and citrinin.

          Toxicology and Applied Pharmacology. 191: 255-263.

Liu, B. H.*, C. Y. Huang, F. Y. Yu, and P. C. Lin. 2003. The prescence and expression of aflR Gene

           in various Aspergillus species.  Food Science and Agricultural  Chemistry. (In Press)

Liu, B. H.*, F. Y. Yu, M. H. Chan, and Y. L. Yang. 2002. The effect on mycotoxins, 

          fumonisins B1 and Aflatoxin B1, on primary swine alveolar macrophages.

          Toxicology and Applied Pharmacology. 180:197-204. 

Yu, F. Y., B. H. Liu, H. N. Chou, and F. S. Chu. 2002. Development of a sensitive 

          ELISA for determination of microcystins in algae. Journal of Agricultural and 

          Food Chemistry 50: 4176-4182. 

  Liu, B.-H., F.-Y. Yu*. 2001. DNA affinity-purified AFLR binds to the 5'

           upstream regions of aflatoxin pathway genes. Food Science and Agricultural 

           Chemistry.3:84-90.

 Li, T-Y., B. H. Liu, and Y. C. Chen. 2000. Characterization of Aspergillus spores by

         matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid

        Commun. Mass Spectrom. 14:2393-2400 (SCI)

    Liu, B. H., F. Y. Yu, X. Huang, and F. S. Chu. 2000. Monitoring of 

         Microcystin-protein phosphatase adduct formation with immunochemical methods.

           Toxicon 38: 619-632. (SCI)

    Liu, B. H., Bhatnagar, D., and F. S. Chu. 1999. Isolation and characterization of 

         sterigmatocystin O-methyltransferase involved in aflatoxin biosynthesis. Natural 

         Toxins  7(4): 1-7         

          associated with aflatoxin biosynthesis. Applied and Environmental Microbiology 64 (10)

          : 3718-3723.(SCI)

     Liu. B. H., J. F. Brewer, J. E. Flahery, G. Payne, D. Bhatnagar, and F. S. Chu. 1997.  

          Immunochemical identification of AFLR, a regulatory protein, involved in aflatoxin 

          biosynthesis. Food and Agricultural Immunology 9: 289-298.(SCI)

          against sterigmatocystin O-methyltransferase. Food and Agricultural Immunology 9: 167-

          176. (SCI)

           generated from polyclonal antibodies against microcystin-LR. Journal of Agricultural and 

           Food Chemistry 44: 4037-4042.(SCI)

    Liu, B. H., N. C. Keller, D. Bhatnagar, T. E. Cleveland, and F. S. Chu. 1993. Production and 

          characterization of antibodies against sterigmatocystin O-methyltransferase. Food and 

          Agricultural Immunology 5:155-164. (SCI)

    Yuan J. N., B. H. Liu, H. Lee, Y. T. Shaw, S.T. Ch iou, W. C. Chang, and M. D. Lai. 1993

            Release of the p-53-induced repression on thymidine kinase promoter by single p53

           -binding sequence. Biochemical  and Biophysical Research Communication. 191(2):662

           -668. (SCI)

    Wang S. L., J. D. Huang, M. D. Lai, B. H. Liu, and M.L. Lai. 1993. Molecular basis of 

           genetic varation in debrisoquin hydroxylation in Chinese subjects:Polymorphism in RFLP 

           and DNA sequence of CYP2D6.  Clinical Pharmacology & Therapeutics 53(4):412-418.  (SCI)